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The role of stratifin in fibroblast–keratinocyte interaction

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Abstract

Stratifin is a member of 14-3-3 protein family, a highly conserved group of proteins constituted by seven isoforms. They are involved in numerous crucial intracellular functions such as cell cycle and apoptosis, regulation of signal transduction pathways, cellular trafficking, cell proliferation and differentiation, cell survival, and protein folding and processing, among others. At epidermal level, stratifin (also called 14-3-3 sigma) has been described as molecule with relevant functions. For instance, this isoform is a marker associated with keratinocyte differentiation. In this maturation process, the presence of dominant negative molecules of p53 induces a “stemness condition” of keratinocyte precursor cells and suppression of stratifin expression. In addition, the recently described keratinocyte-releasable form of stratifin is involved in dermal fibroblast MMP-1 over-expression through c-Fos and c-Jun activity. This effect is mediated, at least in part, by p38 mitogen-activated protein kinase (MAPK). Other MMP family members such as stromelysin-1 (MMP-3), stromelysin-2 (MMP-10), neutrophil collagenase (MMP-8), and membrane-type MMP-24 (MT5-MMP) are also up-regulated by stratifin. Within fibroproliferative disorder of skin, hypertrophic scar and keloids exhibit a high content of collagen, proteoglycans, and fibronectin. Thus, the MMP profile induced by stratifin is an interesting starting point to establish new therapeutic tools to control the process of wound healing. In this review, we will focus on site of synthesis and mode of action of stratifin in skin and wound healing.

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Abbreviations

Elk4:

ETS domain protein

ERK:

Extracellular signal-regulated kinase

ETS:

E twenty-six (Ets) domain transcription factors

KSFM:

Keratinocyte serum-free medium

MAPK:

Mitogen-activated protein kinase

MMP:

Matrix metalloproteinase

NID Box:

Net inhibitory domain of Elk4/Sap1a

Sap1a:

Serum response factor accessory protein 1

SRE:

Serum response element

SRF:

Serum response factor

TAD:

C-terminal transcriptional activation domain of Elk4/Sap1a

TCF:

Ternary complex factor

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  1. BC Professional Fire Fighters’ Burn and Wound Healing Laboratory, Division of Plastic Surgery, University of British Columbia, Vancouver, BC, Canada

    Abelardo Medina, Abdi Ghaffari, Ruhangiz T. Kilani & Aziz Ghahary

  2. Jack Bell Research Centre, 351-2660 Oak Street, Vancouver, BC, Canada, V6H 3Z6

    Aziz Ghahary

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  1. Abelardo Medina
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  4. Aziz Ghahary
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Medina, A., Ghaffari, A., Kilani, R.T. et al. The role of stratifin in fibroblast–keratinocyte interaction. Mol Cell Biochem 305, 255–264 (2007). https://doi.org/10.1007/s11010-007-9538-y

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