Skip to main content
SpringerLink
Log in

Studies of the FABP family: A retrospective

  • Published:
Molecular and Cellular Biochemistry Aims and scope Submit manuscript

Abstract

Following my research on the role played by soluble proteins in their function as hydrophobic ligand carriers acting through squalene epoxidase, Dr Odani and I started to work together on low molecular lipid binding proteins. As a result of this collaboration, in 1982 we managed to determine the complete primary structure of Z-protein in rat liver. This was the first report ever to give the complete amino acid sequence of a fatty acid binding protein (FABP). This gave momentum to further such research, and now extensive exploration has been carried out on a whole family of homologous intracellular hydrophobic ligand binding proteins, the product of the expression of an ancient gene family in numerous organisms. Takahashi et al. have determined the primary structures of mammalian FABP family protein in liver, intestine, heart, kidney, and skin through amino acid sequencing as well as through determination of the cDNA sequence. Out of all my research on the FABP family, I believe, my initial study on FABP in liver, my work on kidney FABP, heart type FABP and my discovery of an I-15P (BAPB) and I-FABP application as a diagnostic marker stand out in particular.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Ockner RK, Manning JA, Poppenhausen RB, Ho WKL: A binding protein for fatty acid in cytosol of intestinal mucosa, liver, myocardium, and other tissues. Science 177: 56–58, 1972

    PubMed  Google Scholar 

  2. Dempsey ME, McCoy KE, Baker HN, Dimitriadou-Vafiadou A, Lorsbach T, Howard JB: Large scale purification and structural characterization of squalene and sterol carrier proteins. J Biol Chem 256: 1867–1873, 1981

    PubMed  Google Scholar 

  3. Levi AJ, Gatmaintan Z, Arias IM: Two hepatic cytoplasmic protein fractions, Y and Z, and possible role in the hepatic uptake of bilirubin, sulfobromophthalein, and other anions. J Clin Invest 48: 2156–2167, 1969

    PubMed  Google Scholar 

  4. Ono T, Bloch K: Solubilization and partial characterization of rat liver squalene epoxidase. J Biol Cem 250: 1571–1579, 1975

    Google Scholar 

  5. Ferguson JB, Bloch K: Purification and properties of a soluble protein activator of rat liver squalene epoxidase. J Biol Chem 252: 5382–5385, 1980

    Google Scholar 

  6. Shibata N, Arita M, Misaki Y, Dohmae N, Taiko K, Ono T, Inoue K, Arai H: Supernatant protein factor, which stimulates the conversion of squalene to lanosterol, is a cytosolic squalene transfer protein and enhances cholesterol biosynthesis. Proc Natl Acad Sci USA 98: 2244–2249, 2001

    Article  PubMed  Google Scholar 

  7. Akeroyd R, Moonen P, Westerman J, Puyk WC, Wirtz KWA: The complete primary structure of the phosphatidylcholine-transfer protein from bovine liver. Isolation and characterization of the cyanogens bromide peptides. Eur J Biochem 14: 385–391, 1981

    Article  Google Scholar 

  8. Bloj B, Hughes ME, Wilson DB, Zilversmit DB: Isolation and amino acid analysis of a nonspecific phospholipid transfer protein from rat liver. FEBS Lett 96: 87–89, 1978

    Article  PubMed  Google Scholar 

  9. Ong DE, Chytil F: Cellular retinal-binding protein from rat liver. Purification and characterization. J Biol Chem 253: 828–832, 1978

    Google Scholar 

  10. Takahashi K, Odani S, Ono T: Primary structure of rat liver Z-protein. A low-Mr cytosol protein that binds sterols, fatty acids and other small molecules. FEBS Lett 140: 63–66, 1982

    Article  PubMed  Google Scholar 

  11. Hertzel V, Bernlohr DA: The mammalian fatty acid-binding protein multigene family: molecular and genetic insights into function. TEM 11: 175–180, 2000

    PubMed  Google Scholar 

  12. Flower DR: Structural relationship of streptavidin to the calycin protein superfamily. FEBS Lett 333: 99–102, 1993

    Article  PubMed  Google Scholar 

  13. Kitamura K, Suzuki M, Suzuki A, Uyemura K: The complete amino acid sequence of the P2 protein in bovine peripheral nerve myelin. FEBS Lett 115: 27–30, 1981

    Article  Google Scholar 

  14. Crabb JW, Saari JC: N-terminal sequence homology among retinoid-binding proteins from bovine retina. FEBS Lett 130: 15–18, 1981

    Article  PubMed  Google Scholar 

  15. Eriksson U, Sundelin J, Rask L, Peterson PA: The NH2-terminal amino acid sequence of cellular retinoic-acid binding protein from rat testis. FEBS Lett 135: 70–72, 1981

    Article  PubMed  Google Scholar 

  16. Takahashi K, Odani S, Ono T: A close structural relationship of rat liver Z-protein to cellular retinoid binding proteins and peripheral nerve myelin P2 protein. Biochem Biophys Res Commun 106: 1099–1105, 1982

    Article  PubMed  Google Scholar 

  17. Haunerland N, Jagschies G, Schulenberg H, Spener F: Fatty-acid-binding proteins. Occurrence of two fatty-acid-binding proteins in bovine liver cytosol and their binding of fatty acids, cholesterol, and othe lipophilic ligands. Hoppe-Seyler’s Z Physiol Chem 365: 365–376, 1984

    PubMed  Google Scholar 

  18. Takahashi K, Odani S, Ono T: Isolation and characterization of the three fractions (DE-I, DE-II and DE-III) of rat liver Z-protein and the complete primary structure of DE-II. Eur J Biochem 136: 589–601, 1983

    Article  PubMed  Google Scholar 

  19. Hitomi M, Odani S, Ono T: Glutathione-protein mixed disulfide decreases the affinity of rat liver fatty acid-binding protein for unsaturated fatty acid. Eur J Biochem 187: 713–719, 1990

    Article  PubMed  Google Scholar 

  20. Odani S, Koide T, Ono T, Aoyagi Y: Analysis of strongly acidic amino acids by the conventional amino acid analyzer: application to deterrmination of protein-bound cysteine and glutathione. Anal Biochem 171: 305–309, 1988

    Article  PubMed  Google Scholar 

  21. Fujii S, Kawaguchi H, Yasuda H: Purification and characterization of fatty acid-binding protein from rat kidney. Arch Biochem Biophys 254: 552–558, 1987

    Article  PubMed  Google Scholar 

  22. Fujii S, Kawaguchi H, Ysuda H: Fatty acid binding protein in kidney of normotensive and genetically hypertensive rats. Hypertension 10: 93–99, 1987

    PubMed  Google Scholar 

  23. Fujii S, Kawaguchi H, Okamoto H, Togashi H, Saito H, Yasuda H: Increased renal fatty acid binding protein in spontaneously hypertensive rats. J Hypertens 6: 671–675, 1988

    PubMed  Google Scholar 

  24. Lam KT, Borkan S, Claffy KP, Schwarz JH, Chobanian AV, Brecher P: Properties and differential regulation of two fatty acid binding proteins in the rat kidney. J Biol Chem 263: 15762–15768, 1988

    PubMed  Google Scholar 

  25. Kimura H, Odani S, Suzuki J, Arakawa M, Ono T: Kidney fatty acid protein: identification as α2U-globulin. FEBS Lett 246: 101–104, 1989

    Article  PubMed  Google Scholar 

  26. Sipple AE, Feigelson P, Roy AK: Hormonal regulation of the hepatic messenger RNA levels for alpha2u globulin. Biochemistry 14: 825–829, 1975

    Article  PubMed  Google Scholar 

  27. Roy AK, Neuhaus OW: Proof of the hepatic synthesis of a sex-dependent protein in the rat. Biochim Biophys Acta 127: 82–87, 1966

    PubMed  Google Scholar 

  28. Kimura H, Odani S, Nishi S, Sato H, Arakawa M, Ono T: Primary structure and cellular distribution of two fatty acid-binding proteins in adult rat kidneys. J Biol Chem 266: 5963–5972, 1991

    PubMed  Google Scholar 

  29. Heucheroth RO, Birkenmeir EH, Levin MS, Gordon JI: Analysis of the tissue specific expression developmental regulation, and linkage relationships of a rodent gene encoding heart fatty acid binding protein. J Biol Chem 262: 9709–9717, 1987

    PubMed  Google Scholar 

  30. Claffey KP, Herrara VL, Brecher P, Ruiz-Opazo N: Cloning and tissue distribution of rat heart fatty acid binding protein mRNA: identical forms in heart and skeletal muscle. Biochemistry 26: 7900–7904, 1987

    Article  PubMed  Google Scholar 

  31. Kimura H, Hitomi M, Odani S, Koide T, Arakawa M, Ono T: Rat heart fatty acid-binding protein. Evidence that supports the amino acid sequence predicted from cDNA. Biochem J 260: 303–306, 1989

    Google Scholar 

  32. Kanda T, Iseki S, Hitomi M, Kimura H, Odani S, Kondo H, Matsubara Y, Muto T, Ono T: Purification and characterization of a fatty-acid-binding protein from the gastric mucosa of rats. Possible identity with heart fatty-acid-binding protein and its parietal cell localization. Eur J Biochem 185: 27–33, 1989

    Article  PubMed  Google Scholar 

  33. Peeters RA, Veerkamp JH, van Kessel AG, Kanda T, Ono T: Cloning of the cDNA encoding human skeletal-muscle fatty-acid-binding protein, its peptide sequence and chromosomal localization. Biochem J 276: 203–207, 1991

    PubMed  Google Scholar 

  34. Sakai K, Fujii H, Yamamoto T, Sakakibara J, Izumi T, Shibita A, Ono T: Tissue-specific suppression of aortic fatty acid-binding protein in streptozotocin-induced diabetic rats. Eur J Biochem 229: 201–206, 1995

    Article  PubMed  Google Scholar 

  35. Kanda T, Odani S, Tomoi M, Matsubara Y, Ono T: Primary structure of a 15-kDa protein from rat intestinal epithelium. Sequence similarity to fatty-acid-binding proteins. Eur J Biochem 197: 759–768, 1991

    Article  PubMed  Google Scholar 

  36. Wilder MD,Vinik AI, Heldsinger A: Isolation and partial characterization of an entero-oxyntin from porcine ileum. Endocrinology 115: 1484–1491, 1984

    PubMed  Google Scholar 

  37. Alpers HD, Strauss AW, Ockner RK, Bass NM, Gordon JL: Cloning of a cDNA encoding rat intestinal fatty acid binding protein. Proc Natl Acad Sci USA 81: 313–317, 1984

    PubMed  Google Scholar 

  38. Kitamura K, Suzuki A, Uyemura K: The complete amino acid sequence of the P2 protein in bovine peripheral nerve myelin. FEBS Lett 115: 27–30, 1980

    Article  PubMed  Google Scholar 

  39. Bernlohr DA, Angus CW, Lane MD, Bolanowski MA, Kelly TJ, Jr: Expression of a specific mRNAs during adipose differentiation: identification of an mRNA encoding a homologue o myelin P2 protein. Proc Natl Acad Sci USA 81: 5468–5472, 1984

    PubMed  Google Scholar 

  40. Iseki S, Amano O, Kanda T, Fujii H, Ono T: Expression and localization of intestinal 15 kDa protein in the rat. Mol Cell Biochem 123: 113–120, 1993

    Article  PubMed  Google Scholar 

  41. Amano O, Kanda T, Ono T, Iseki S: Immunocytochemical localization of rat intestinal 15 kDa protein, a member of cytoplasmic fatty acid-binding proteins. Anat Rec 234: 215–222, 1992

    Article  PubMed  Google Scholar 

  42. Fujita M, Fujii H, Kanda T, Sato E, Hatakeyama K, Ono T: Molecular cloning, expression, and characterization of a human intestinal 15-kDa protein. Eur J Biochem 233: 406–413, 1995

    Article  PubMed  Google Scholar 

  43. Sato E, Fujii H, Fujita M, Kanda T, Iseki S, Hatakeyama K, Tanaka T, Ono T: Tissue-specific regulation of the expression of rat intestinal bile acid-binding protein. FEBS Lett 374: 184–186, 1995

    Article  PubMed  Google Scholar 

  44. Kanda T, Niot I, Foucaud H, Fujii H, Bernard A, Ono T, Besnard P: Effect of bile on the intestinal bile-acid binding protein (I-BABP) expression In vitro and in vivo studies. FEBS Lett 384: 131–134, 1996

    Article  PubMed  Google Scholar 

  45. Kanda T, Foucaud L, Nakamura Y, Niot I, Bersnard P, Fujita M, Sakai Y, Hatakeyama K, Ono T, Fujii H: Regulation of expression of human intestinal bile acid-binding protein in Coca-2 cell. Biochem J 330: 261–265, 1998

    PubMed  Google Scholar 

  46. Grober J, Zaghini I, Fujii H, Jones SJ, Kliewer SA, Willson TM, Ono T, Besnard P: Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X-receptor/9-cis-retinoic acid receptor heterodimer. J Biol Chem 274: 29749–29754, 1999

    Article  PubMed  Google Scholar 

  47. Kanda T, Nakatomi Y, Ishikawa H, Hitomi M, Matsubara Y, Ono T, Muto T: Intestinal fatty acid-binding protein as a sensitive marker of intestinal ischemia. Dig Dis Sci 37: 1462–1327, 1992

    Article  Google Scholar 

  48. Kanda T, Fujii H, Fujita M, Sakai Y, Ono T, Hatakeyama K: Intestinal fatty acid-binding protein is available for diagnosis of intestinal ischaemia: immunohistochemical analysis of two patients with ischaemic intestinal diseases. Gut 36: 788–791, 1995

    PubMed  Google Scholar 

  49. Kanda T, Fujii H, Tani T, Murakami H, Suda T, Sakai Y, Ono T, Hatakeyama K: Intestinal fatty acid-binding protein is a useful diagnostic marker for mesenteric infarction in humans. Gastroenterology 110: 339–343, 1996

    Article  PubMed  Google Scholar 

  50. Watanabe R, Fujii H, Odani S, Sakakibara J, Yamamoto A, Ito M, Ono T: Molecular cloning of a cDNA encoding a novel fatty acid-binding protein from rat skin. Biochem Biophys Res Commun 200: 253–259, 1994

    Article  PubMed  Google Scholar 

  51. Watanabe R, Fujii H, Yamamoto A, Hashimoto T, Kameda K, Ito M, Ono T: Immunohistochemical distribution of cutaneous fatty acid-binding protein in human skin. J Dermatol Sci 16: 17–22, 1997

    Article  PubMed  Google Scholar 

  52. Yamaguchi H, Yamamoto A, Watanabe R, Uchiyama N, Fijii H, Ono T, Ito M: High transepidermal water loss Induces fatty acid synthesis and cutaneous fatty acid-binding protein expression in rat skin. J Dermatol Sci 17: 205–213, 1998

    Article  PubMed  Google Scholar 

  53. Odani S, Namba Y, Ishi A, Ono T, Fujii H: Disulfide bonds in rat cutaneous fatty acid-binding protein. J Biochem 128: 355–361, 2000

    PubMed  Google Scholar 

  54. Kanda T, Ono T, Matsubara Y, Muto T: Possible role of fatty acid-binding proteins in the intestine as a carriers of phenol and phthalate derivatives. Biochem Biophys Res Commun 168: 1053–1058, 1990

    Article  PubMed  Google Scholar 

  55. Senjo M, Ishibashi T, Imai Y, Takahashi K, Ono T: Isolation and characterization of fatty acid-binding protein from rat brain. Arch Biochem Biophys 236: 662–668, 1985

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Dairy Science, Laboratory of Clinical Nutrition, Rakuno Gakuen University, 582-1 Midorimachi Bunkyodai, Ebetsu, 069-8501, Japan

    Teruo Ono (MD)

Authors
  1. Teruo Ono
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Teruo Ono.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ono, T. Studies of the FABP family: A retrospective. Mol Cell Biochem 277, 1–6 (2005). https://doi.org/10.1007/s11010-005-4816-z

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11010-005-4816-z

Keywords

Search

Navigation