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Association of the Ile50Val Polymorphism of the Interleukin-4 Receptor Gene IL4RA with Chronic Viral Hepatitis

  • Genomics. Transcriptomics. Proteomics
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Abstract

The Ile50Val polymorphism of the IL4RA gene was tested for association with chronic viral hepatitis and the character of its progression (the stage of hepatic fibrosis). In total, 61 patients were examined. The control group was a random sample of Tomsk residents (N = 128). Genotyping was based on RFLP analysis. The allele and genotype frequencies of the Ile50Val polymorphism did not significantly differ between the patients and the controls. However, a significant difference in genotype frequency distribution was observed for the patients with different stages of hepatic fibrosis. The frequency of heterozygotes Ile/Val in patients without signs of fibrosis was lower than in the control group (7.1% vs. 51.6%, P = 0.002), while the frequency of the homozygous genotypes was higher. In addition, this subgroup significantly differed in genotype frequency distribution from subgroups of patients with early or severe fibrosis (P = 0.035 and P = 0.004, respectively).

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REFERENCES

  1. O’Brien S.J., Nelson G. W. 2004. Human genes that limit AIDS. Nature Genetics. 36, 565–574.

    CAS  PubMed  Google Scholar 

  2. Kwiatkowski D. 2000. Susceptibility to infection. Br. Med. J. 321(28), 1061–1065.

    CAS  Google Scholar 

  3. Gonzalez E., Dhanda R., Bamshard M., et al. 2001. Global survey of genetic variation in CCR5, RANTES and MIP-1: Impact on the epidemiology of the HIV-1 pandemic. Proc. Natl. Acad. Sci. USA. 98, 5199–5204.

    CAS  PubMed  Google Scholar 

  4. Dessein A.J., Chevillard C., Marquet S., et al. 2001. Genetics of parasitic infections. Drug metabolism disposition. 29, 484–488.

    CAS  Google Scholar 

  5. Lipsitch M., Sousa A. 2002. Historical intensity of natural selection for resistance to tuberculosis. Genetics. 161, 1599–1607.

    PubMed  Google Scholar 

  6. Roy S., Hill A. 2002. Association of common genetic variant with susceptibility to invasive pneumococcal disease. Br. Med. J. 324, 1369.

    CAS  Google Scholar 

  7. Plebanski M., Proudfoot O., Pouniotis D., et al. 2002. Immunogenetics and the design of Plasmodium falciparum vaccines for use in malaria-endemic populations. J. Clin. Invest. 110, 295–301.

    CAS  PubMed  Google Scholar 

  8. Yagoda A.V., Geivandova N.I., Khubiev Sh.Kh., et al. 2000. Immunologiya. 2, 36–38.

    Google Scholar 

  9. Ivashkin V.T., Bueverov A.O., Gryazin A.E. 2004. Mechanisms of hepatitis C virus resistance to antiviral drugs. Mol. Meditsina. 2, 18–23.

    Google Scholar 

  10. Sennikov S.V., Kuramshin D.Kh., Tolokonskaya N.P., Kozlov V.A. 2003. Gene expression and production of main immunoregulatory cytokines in viral hepatitis C. Tsitokiny i Vospalenie. 4, 1–4.

    Google Scholar 

  11. Ivashkin V.T., Mamaev S.N., Lukina E.A., et al. 2001. The cytokine system in patients with chronic diffuse liver diseases. Immunologiya. 1, 46–48.

    Google Scholar 

  12. Tsaregorodtseva T.M., Serova T.I. 2003. Tsitokiny v gas-troenterologii (Cytokines in Gastroenterology). Moscow: Anakharsis.

    Google Scholar 

  13. Mitsuyasu H., Yanagihara Y., Mao X.-Q. et al. 1999. Cutting edge: Dominant effect of Ile50Val variant of the human Il-4 receptor alpha-chain IgE synthesis. J. Immunol. 162, 1227–1231.

    CAS  PubMed  Google Scholar 

  14. Howard T.D., Wiesch D.G., Postma D.S., et al. 1998. Linkage and association study of the IL4 receptor (IL4R) gene on chromosome 16 in asthma and allergic phenotype. Am. J. Hum. Genet. 63(Suppl), 293.

    Google Scholar 

  15. Puzyrev V.P., Freidin M.B. 1999. Role if interleukin genes and receptors in predisposition to bronchial asthma. Byull. Eksp. Biol. Med. 127(Suppl. 1), 3–6.

    Google Scholar 

  16. Mirel D.B., Valdes A.M., Lazzeroni L.C. et al. 2002. Association of IL4R haplotypes with type 1 diabetes. Diabetes. 51, 3336–3341.

    CAS  PubMed  Google Scholar 

  17. Vasilescu A., Heath S.C., Ivanova R., et al. 2003. Genomic analysis of Th1-Th2 cytokine genes in an AIDS cohort: Identification of IL4 and IL10 haplotypes associated with the disease progression. Genes Immun. 4, 441–449.

    CAS  PubMed  Google Scholar 

  18. Choi E.H., Lee H.J., Yoo T., Chanock S.J. 2002. A common haplotype of interleukin-4 gene IL4 is associated with severe respiratory syncytial virus disease in Korean children. J. Infect. Dis. 186, 1207–1211.

    CAS  PubMed  Google Scholar 

  19. Knodell R.G., Ishak R.G., Black W.S., et al. 1981. Formulation and application of numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology. 1, 431–435.

    CAS  PubMed  Google Scholar 

  20. Desmet V.J., Gerber M., Hoofnagle J.H., et al. 1994. Classification of chronic hepatitis: Diagnosis, grading and staging. Hepatology. 19, 1513–1520.

    Article  CAS  PubMed  Google Scholar 

  21. Lahiri D.K., Bye S., Nunberg J.I., et al. 1992. A non-organic and non-enzymatic extraction method gives higher yields of genomic DNA from whole-blood samples than do nine other methods used. J. Biochem. Biophys. Methods. 25, 193–205.

    CAS  PubMed  Google Scholar 

  22. Mitsuyasu H., Izuhara K., Mao X.-Q., et al. 1998. Ile50Val variants or Il4R? upregulates IgE synthesis and associates with atopic asthma. Nature Genet. 19, 119–120.

    CAS  PubMed  Google Scholar 

  23. Noguchi E., Shibasaki M., Arinami T., et al. 1999. Lack of association of atopy/asthma and the interleukin-4 receptor α gene in Japanese. Clin. Exp. Allergy. 29, 228–233.

    CAS  PubMed  Google Scholar 

  24. Lakin G.F. 1990. Biometriya (Biometry), Moscow: Nauka.

    Google Scholar 

  25. He J.O., Connett J.E., Anthonisen N.R., Sandford A.J. 2003. Polymorphisms in the IL13, IL13RA1, and IL4RA genes and rate to decline in lung function in smokers. Am. J. Respir. Cell Mol. Biol. 28, 379–385.

    CAS  PubMed  Google Scholar 

  26. Ober C., Leavitt S.A., Tsalenko A., et al. 2000. Variation in the interleukin 4-receptor gene confers susceptibility to asthma and atopy in ethnically diverse population. Am. J. Hum. Genet. 66, 517–526.

    CAS  PubMed  Google Scholar 

  27. Noguchi E., Shibasaki M., Arinami T. et al. 1999. No association between atopy/asthma and the Ile50Val polymorphism of IL-4 receptor. Am. Respir. Crit. Care Med. 160, 342–345.

    CAS  Google Scholar 

  28. Puzyrev V.P., Freidin M.B., Ogorodova L.M., Kobyakova O.V. 2002. Interrelation of polymorphic variants of interleukine genes and receptors with atopic bronchial asthma. Med. Genet. 1, 86–92.

    Google Scholar 

  29. Spiridonova M.G., Stepanov V.A., Puzyrev V.P. 2001. On the role of polymorphic variants of the 5,10-methylene tetrahydrofolate reductase gene (MTHFR) in pathogenesis of cardiovascular diseases. Klin. Med. 2, 10–16.

    Google Scholar 

  30. Freidin M.B., Bragina E.Yu., Ogorodova L.M., Puzyrev V.P. 2002. Polymorphism of glutathione transferase 1 and 1 genes (GSTT1 and GSTM1) in patients with atopic bronchial asthma in the Western Siberian Region. Mol. Biol. 36, 1–5.

    Article  Google Scholar 

  31. Ivashchenko, T.E., Strekalov D.L., Solov’eva D.V., et al. 2004. Testing for genetic predisposition to multifactor diseases and the genetic passport. In: Molekulyarno-biologicheskie tekhnologii v meditsinskoi praktike (Molecular-Biological Technologies in Practical Medicine), Novosibirsk: Al’ta Vista, pp. 9–28.

    Google Scholar 

  32. Wilson M.H., Grant P.J., Hardie L.J., Wild C.P. 2000. Glutatione S-transferase M1 null genotype is associated with a decreased risk of myocardial infarction. FASEB Lett. 14, 791–796.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Medical Genetics, Tomsk Research Center, Siberian Division, Russian Academy of Sciences, Tomsk, 634050, Russia

    I. A. Goncharova, M. B. Friedin & V. P. Puzyrev

  2. Department of Therapy, Siberian State Medical University, Tomsk, 634050, Russia

    L. E. Dunaeva & E. I. Beloborodova

  3. Department of Hospital Therapy, Siberian State Medical University, Tomsk, 634050, Russia

    E. V. Beloborodova

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  1. I. A. Goncharova
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  2. M. B. Friedin
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  3. L. E. Dunaeva
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  4. E. V. Beloborodova
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  5. E. I. Beloborodova
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  6. V. P. Puzyrev
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__________

Translated from Molekulyarnaya Biologiya, Vol. 39, No. 3, 2005, pp. 379–384.

Original Russian Text Copyright © 2005 by Goncharova, Friedin, Dunaeva, E.V. Beloborodova, E.I. Beloborodova, Puzyrev.

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Goncharova, I.A., Friedin, M.B., Dunaeva, L.E. et al. Association of the Ile50Val Polymorphism of the Interleukin-4 Receptor Gene IL4RA with Chronic Viral Hepatitis. Mol Biol 39, 336–340 (2005). https://doi.org/10.1007/s11008-005-0047-3

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  • DOI: https://doi.org/10.1007/s11008-005-0047-3

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