Abstract
Fetal alcohol spectrum disorders (FASD) are associated with an increase in risk for mortality for people with an FASD and their siblings. In this study we examine mortality rates of birth mothers of children with FASD, using a retrospective case control methodology. We utilized the North Dakota FASD Registry to locate birth certificates for children with FASD which we used to identify birth mothers. We then searched for mothers’ death certificates. We then compared the mortality rates of the birth mothers with an age matched control group comprised of all North Dakota women who were born and died in the same year as the birth mother. The birth mothers of children with FASD had a mortality rate of 15/304 = 4.93%; (95% CI 2.44–7.43%). The mortality rate for control mothers born in same years as the FASD mothers was 126/114,714 = 0.11% (95% CI 0.09–0.13%). Mothers of children with an FASD had a 44.82 fold increase in mortality risk and 87% of the deaths occurred in women under the age of 50. Three causes of death (cancer, injuries, and alcohol related disease) accounted for 67% of the deaths in the mothers of children with FASD. A diagnosis of FASD is an important risk marker for premature death in the mothers of children diagnosed with an FASD. These women should be encouraged to enter substance abuse treatment.
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Rehm, J., Mathers, C., Popova, S., Thavorncharoensap, M., Teerawattananon, Y., & Patra, J. (2009). Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders. Lancet, 373(9682), 2223–2233.
Durkin, A., Connolly, S., & O’Reilly, D. (2010). Quantifying alcohol-related mortality: Should alcohol-related contributory causes of death be included? Alcohol Alcohol, 45(4), 374–378.
Smith, L. A., & Foxcroft, D. R. (2009). The effect of alcohol advertising, marketing and portrayal on drinking behaviour in young people: Systematic review of prospective cohort studies. BMC Public Health, 9, 51.
Zaridze, D., Brennan, P., Boreham, J., Boroda, A., Karpov, R., Lazarev, A., et al. (2009). Alcohol and cause-specific mortality in Russia: A retrospective case-control study of 48, 557 adult deaths. Lancet, 373(9682), 2201–2214.
Di, C. A., Costanzo, S., Bagnardi, V., Donati, M. B., Iacoviello, L., & de Gaetano, G. (2006). Alcohol dosing and total mortality in men and women: An updated meta-analysis of 34 prospective studies. Annals of Internal Medicine, 166(22), 2437–2445.
Baker, A., & Rooney, C. (2003). Recent trends in alcohol-related mortality, and the impact of ICD-10 on the monitoring of these deaths in England and Wales. Health Statistics Quarterly, 17, 5–14.
Hemström, Ö. (2002). Alcohol-related deaths contribute to socioeconomic differentials in mortality in Sweden. The European Journal of Public Health, 12(4), 254–262.
Mäkelä, P. I. A. (1998). Alcohol-related mortality by age and sex and its impact on life expectancy. The European Journal of Public Health, 8(1), 43–51.
Di Castelnuovo, A., Costanzo, S., Bagnardi, V., Donati, M. B., Iacoviello, L., & de Gaetano, G. (2006). Alcohol dosing and total mortality in men and women: An updated meta-analysis of 34 prospective studies. Annals of Internal Medicine, 166(22), 2437–2445.
Miller, N. S. (1999). Mortality risks in alcoholism and effects of abstinence and addiction treatment. Psychiatric Clinics of North America, 22(2), 371–383.
Centers for Disease Control, Prevention. (2004). Alcohol-attributable deaths and years of potential life lost—United States, 2001. Morbidity and Mortality Weekly Report (WWMR), 53(37), 866–870.
Centers for Disease Control, Prevention. (2009). Alcohol use among pregnant and nonpregnant women of childbearing age—United States, 1991–2005. Morbidity and Mortality Weekly Report (WWMR), 58(19), 529–532.
Caetano, R., Ramisetty-Mikler, S., Floyd, L. R., & McGrath, C. (2006). The epidemiology of drinking among women of child-bearing age. Alcoholism, Clinical and Experimental Research, 30(6), 1023–1030.
Floyd, R. L., Decoufle, P., & Hungerford, D. W. (1999). Alcohol use prior to pregnancy recognition. American Journal of Preventive Medicine, 17(2), 101–107.
Stratton, K. R., Howe, C. J., Battaglia, F. C., & Institute of Medicine. (1996). Fetal alcohol syndrome-diagnosis, epidemiology, prevention, and treatment. Washington: National Academy Press.
Sampson, P. D., Streissguth, A. P., Bookstein, F. L., Little, R. E., Clarren, S. K., Dehaene, P., et al. (1997). Incidence of fetal alcohol syndrome and prevalence of alcohol-related neurodevelopmental disorder. Teratology, 56(5), 317–326.
Poitra, B. A., Marion, S., Dionne, M., Wilkie, E., Dauphinais, P., Wilkie-Pepion, M., et al. (2003). A school based screening program for fetal alcohol syndrome. Neurotoxicology and Teratology, 25(6), 731–736.
May, P. A., Gossage, J. P., Marais, A. S., Adnams, C. M., Hoyme, H. E., Jones, K. L., et al. (2007). The epidemiology of fetal alcohol syndrome and partial FAS in a South African community. Drug and Alcohol Dependence, 88(2–3), 259–271.
Burd, L., & Wilson, H. (2004). Fetal infant, and child mortality in a context of alcohol use. American Journal of Medical Genetics Part C Seminars in Medical Genetics, 127(1), 51–58.
Burd, L., Klug, M. G., Bueling, R., Martsolf, J., Olson, M., & Kerbeshian, J. (2008). Mortality rates in subjects with fetal alcohol spectrum disorders and their siblings. Birth Defects Research Part A Clinical and Molecular Teratology, 82(4), 217–223.
Clarren, S. K., & Smith, D. W. (1978). The fetal alcohol syndrome. The New England Journal of Medicine, 298(19), 1063–1067.
Olegard, R., Sabel, K. G., Aronsson, M., Sandin, B., Johansson, P. R., Carlsson, C., et al. (1979). Effects on the child of alcohol abuse during pregnancy. Retrospective and prospective studies. Acta Paediatrica, 68, 112–121.
Streissguth, A. P., LaDue, R., & Randelsk, S. (1987). Indian adolescents and adults with fetal alcohol syndrome: Findings and recommendations. IHS Primary Care Provider, 12, 89–91.
Berg, J. P., Lynch, M. E., & Coles, C. D. (2008). Increased mortality among women who drank alcohol during pregnancy. Alcohol, 42(7), 603–610.
Kvigne, V. L., Leonardson, G. R., Borzelleca, J., Brock, E., Neff-Smith, M., & Welty, T. K. (2003). Characteristics of mothers who have children with fetal alcohol syndrome or some characteristics of fetal alcohol syndrome. Journal of the American Board of Family Practice, 16(4), 296–303.
Abel, E. L. (1998). Fetal alcohol abuse syndrome. New York: Plenum Press.
Astley, S. J. (2010). Profile of the first 1, 400 patients receiving diagnostic evaluations for fetal alcohol spectrum disorder at the Washington state fetal alcohol syndrome diagnostic and prevention network. The Canadian Journal of Clinical Pharmacology, 17(1), e132–e164.
Burd, L., Klug, M. G., Li, Q., Kerbeshian, J., & Martsolf, J. T. (2010). Diagnosis of fetal alcohol spectrum disorders: A validity study of the fetal alcohol syndrome checklist. Alcohol, 44, 605–614.
Hoyme, H. E., May, P. A., Kalberg, W. O., Kodituwakku, P., Gossage, J. P., Trujillo, P. M., et al. (2005). A practical clinical approach to diagnosis of fetal alcohol spectrum disorders: Clarification of the 1996 institute of medicine criteria. Pediatrics, 115(1), 39–47.
Revisions of the International Classification of Diseases (ICD-9, ICD-10). (1996). Impact on health statistics. Epidemiology Bulletin, 17(2), 1–5.
Arias, E., MacDorman, M. F., Strobino, D. M., & Guyer, B. (2003). Annual summary of vital statistics-2002. Pediatrics, 112(6 Pt 1), 1215–1230.
Cipriani, F., Cucinelli, M. L., Dimauro, P. E., Angioli, D., Conte, M., Voller, F., et al. (2001). Mortality in a cohort of alcoholics from Arezzo in 1979–1997. Epidemiologia e Prevenzione, 25(2), 63–70.
Feuerlein, W., Kufner, H., & Flohrschutz, T. (1995). The mortality rate of alcoholic patients 4 years after inpatient treatment. Versicherungsmedizin, 47(1), 10–14.
Stinson, F. S., & DeBakey, S. F. (1992). Alcohol-related mortality in the United States, 1979–1988. British Journal of Addiction, 87(5), 777–783.
Gual, A., Lligona, A., Costa, S., Segura, L., & Colom, J. (2004). Long term impact of treatment in alcoholics. Results from a 10 year longitudinal follow-up study of 850 patients. Medicina Clinica (Barcelona), 123(10), 364–369.
Martin, J. A., Hamilton, B. E., Sutton. P. D., Ventura, S. J., Mathews, T. J., Kirmeyer, S., et al. (2010). Births: Final data for 2007. Hyattsville: National Center for Health Statistics. Report No. 58.
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Li, Q., Fisher, W.W., Peng, CZ. et al. Fetal Alcohol Spectrum Disorders: A Population Based Study of Premature Mortality Rates in the Mothers. Matern Child Health J 16, 1332–1337 (2012). https://doi.org/10.1007/s10995-011-0844-3
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DOI: https://doi.org/10.1007/s10995-011-0844-3