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Maternal HIV/AIDS Status and Neurological Outcomes in Neonates: A Population-Based Study

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Abstract

This study sought to examine the association between maternal HIV/AIDS infection and neonatal neurologic conditions in the state of Florida. We analyzed all births in the state of Florida from 1998 to 2007 using hospital discharge data linked to birth certificate records. The main outcomes of interest included selected neonatal neurologic complications, namely: fetal distress, cephalohematoma, intracranial hemorrhage, seizure, feeding difficulties, and other central nervous system complications. The sample size for this study was 1,645,515 records. All forms of substance abuse as well as cesarean section deliveries were more frequent in mothers with HIV/AIDS. Infants born to HIV-infected mothers showed higher proportions of feeding difficulties and seizures whereas HIV-negative mothers had a greater proportion of cases of fetal distress and cephalohematoma. Seizures and feeding difficulties are common among infants born to HIV/AIDS infected mothers. This population-based retrospective cohort study provides further understanding of the association between maternal HIV/AIDS status and neonatal neurological outcomes.

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Acknowledgments

We thank the Florida Department of Health and Florida Agency for Health Care Administration for providing the data files used in this study.

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Authors and Affiliations

  1. Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, 13201 Bruce B. Downs Blvd., MDC 56, Tampa, FL, 33612, USA

    Hamisu M. Salihu, Hanna Weldeselasse & Alfred K. Mbah

  2. Department of Obstetrics and Gynecology, College of Medicine, University of South Florida, 2 Tampa General Circle, STC 6th floor, Tampa, FL, 33606, USA

    Hamisu M. Salihu

  3. Department of Community and Family Health, College of Public Health, University of South Florida, 13201 Bruce B. Downs Blvd., MDC 56, Tampa, FL, 33612, USA

    Euna M. August

  4. Department of Preventive Medicine, Vanderbilt Institute for Global Health, 2525 West End Avenue, Suite 750, Nashville, TN, 37203, USA

    Muktar Aliyu

  5. Maine Center for Disease Control, 286 Water Street, 8th floor, Augusta, ME, 04333, USA

    Kara M. Stanley

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  1. Hamisu M. Salihu
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Correspondence to Hamisu M. Salihu.

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Salihu, H.M., August, E.M., Aliyu, M. et al. Maternal HIV/AIDS Status and Neurological Outcomes in Neonates: A Population-Based Study. Matern Child Health J 16, 641–648 (2012). https://doi.org/10.1007/s10995-011-0799-4

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  • DOI: https://doi.org/10.1007/s10995-011-0799-4

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