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Nociceptin/Orphanin FQ (N/OFQ) Receptors are Involved in Adrenaline-Induced Feeding Behavior in Broiler Cockerels

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Abstract

Nociceptin/orphanin FQ (N/OFQ) is an endogenous ligand of a G protein-coupled receptornamed NOP. This neuropeptide has been identified as an orexigenic stimulus in the brain of birds and mammals. The purpose of the present study was to clarify whether blockade or stimulation of nociceptin receptors affects adrenaline-induced feeding behaviour in broilers. In Experiment 1, birds received intracerebroventricular (ICV) injection of Nociceptin (1–13) NH2 (potent NOP receptor agonist, 16 nmol) followed by adrenaline (80 nmol). In Experiment 2, the birds received UFP-101, (NOP receptor antagonist, 10 nmol) prior to injection of adrenaline (80 nmol). Cumulative food and water intake was measured at 2 h post-injection. When administrated alone, adrenaline significantly increased food and water intake. The ICV injection of Nociceptin (1–13) NH2 significantly increased food intake but not water intake. Pre-injection of Nociceptin (1–13) NH2 significantly increased the adrenaline-induced feeding response. The effect of adrenaline on food intake was transiently blocked by microinjection of UFP-101. UFP-101-induced anorexia was accompanied by a transient increase in water intake. The transient dipsogenic effect of UFP-101 suggests a role of endogenous N/OFQ-NOP receptor pathways in the regulation of water intake in chickens, which is food intake-independent. These results also provide further evidence for a reciprocal interaction between adrenergic receptors and N/OFQ on feeding behavior.

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Acknowledgements

This research was supported by a grant from Research Council of the University of Zabol. The authors appreciate the technical assistance of M. Salehi. The authors wish to thank Professor Nigel Calcutt for his helps in editing the manuscript.

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Authors and Affiliations

  1. Department of Basic Veterinary Science, Faculty of Veterinary Medicine, University of Zabol, Zabol, Iran

    M. R. Hajinezhad

  2. Department of Biology, School of Basic Sciences, University of Zabol, Zabol, Iran

    P. Hasanein

  3. Research Center of Special Domestic Animals, Research Institute at University of Zabol, Zabol, Iran

    A. Mokhtarpour

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  1. M. R. Hajinezhad
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  2. P. Hasanein
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  3. A. Mokhtarpour
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Correspondence to M. R. Hajinezhad.

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This article does not contain any studies with human participants performed by any of the authors. Animal handling and experimental procedures were performed according to the guideline for Care and Use of Animals Laboratory published by the US National Institute of Health (NIH publication No 85-23, revised 1996) and the current laws of Iran.

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Hajinezhad, M.R., Hasanein, P. & Mokhtarpour, A. Nociceptin/Orphanin FQ (N/OFQ) Receptors are Involved in Adrenaline-Induced Feeding Behavior in Broiler Cockerels. Int J Pept Res Ther 24, 403–407 (2018). https://doi.org/10.1007/s10989-017-9623-3

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  • DOI: https://doi.org/10.1007/s10989-017-9623-3

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