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Systematic Review: Insight into Antimalarial Peptide

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Abstract

Antimalarial peptides varying in size, sequence, charge, conformation and structure, hydrophobicity and amphipathicity reflect their heterogeneity in antimalarial activity. Due to global concern of antimalarial drug resistance, these peptides are seldom in attention for therapeutic values as this microbial and synthetic peptide are likely known for delaying the drug resistance phenomenon. Despite of this, among most of the peptides that have shown activity in cultured parasitized erythrocytes were failing to show its efficacy on in vivo models and few of them that are efficacious are not clinically significant on the host. A systematic literature search was carried out to obtain all related studies in PubMed, EMBASE and GOOGLE SCHOLAR from year 1989 to till date 2015 and we found only 63 studies that focus on antimalarial activity of different peptides originated from different sources under in vitro and in vivo conditions. Antimalarial peptides that are mostly included in this review is the naturally occurring along with their derivatives obtained from different sources ranging from lower prokaryotes to higher eukaryotes. Most of the antimalarial peptides had undergone only in vitro testing on Plasmodium falciparum strains having very less potency, but higher selectivity in comparison to standard drugs. The study included in this article will give future direction for development of more antimalarial peptide with desired efficacy and safety.

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  1. Department of Medical Parasitology, Postgraduate Institute of Medical Education and Research, PGIMER, Research Block-A, Ground Floor, Chandigarh, 160012, India

    Shweta Sinha & Rakesh Sehgal

  2. Department of Pharmacology, Postgraduate Institute of Medical Education and Research, PGIMER, Research Block-B, Fourth Floor, Chandigarh, 160012, India

    Ashutosh Singh

  3. Department of Pharmacology, Postgraduate Institute of Medical Education and Research, PGIMER, Research Block-B, Fourth Floor, Room No 4043, Chandigarh, 160012, India

    Bikash Medhi

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Sinha, S., Singh, A., Medhi, B. et al. Systematic Review: Insight into Antimalarial Peptide. Int J Pept Res Ther 22, 325–340 (2016). https://doi.org/10.1007/s10989-016-9512-1

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  • DOI: https://doi.org/10.1007/s10989-016-9512-1

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