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Synthesis of N-Z, N′-Formyl α-Amino Acid Derived Gem-Diamines

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Abstract

A variety of N-carbobenzoxy, N′-formyl gem-diaminoalkyl derivatives have been obtained through Goldsmith-Wick reaction of Z-α-amino acid/peptide acid derived isocyanates with 96% HCOOH in presence of 4-dimethylaminopyridine (DMAP) as catalyst. The reaction proceeds to completion within 2–4 h and results in good yields of the products isolated as stable solids.

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Acknowledgements

We are grateful to the Council of Scientific & Industrial Research, Govt. of India for financial support and S.I.F and M.B.U of I.I.Sc., Bangalore for providing NMR and mass facilities.

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Authors and Affiliations

  1. Peptide Research Laboratory, Department of Studies in Chemistry, Central College Campus, Bangalore University, Dr. B. R. Ambedkar Veedhi, Bangalore, 560 001, Karnataka, India

    Vommina V. Sureshbabu & N. Narendra

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  1. Vommina V. Sureshbabu
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  2. N. Narendra
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Correspondence to Vommina V. Sureshbabu.

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Sureshbabu, V.V., Narendra, N. Synthesis of N-Z, N′-Formyl α-Amino Acid Derived Gem-Diamines. Int J Pept Res Ther 14, 201–207 (2008). https://doi.org/10.1007/s10989-008-9127-2

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  • DOI: https://doi.org/10.1007/s10989-008-9127-2

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