Abstract
Standard methods for estimating the effect of a time-varying exposure on survival may be biased in the presence of time-dependent confounders themselves affected by prior exposure. This problem can be overcome by inverse probability weighted estimation of Marginal Structural Cox Models (Cox MSM), g-estimation of Structural Nested Accelerated Failure Time Models (SNAFTM) and g-estimation of Structural Nested Cumulative Failure Time Models (SNCFTM). In this paper, we describe a data generation mechanism that approximately satisfies a Cox MSM, an SNAFTM and an SNCFTM. Besides providing a procedure for data simulation, our formal description of a data generation mechanism that satisfies all three models allows one to assess the relative advantages and disadvantages of each modeling approach. A simulation study is also presented to compare effect estimates across the three models.
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Young, J.G., Hernán, M.A., Picciotto, S. et al. Relation between three classes of structural models for the effect of a time-varying exposure on survival. Lifetime Data Anal 16, 71–84 (2010). https://doi.org/10.1007/s10985-009-9135-3
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DOI: https://doi.org/10.1007/s10985-009-9135-3