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Human adipocyte-derived factors directly inhibit cardiac contraction

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Abstract

Obesity is a major risk factor for metabolic syndrome and cardiovascular disorders. Obesity related heart disease is the most serious complication of human obesity. Despite several investigations the pathophysiological mechanisms involved remain unclear. Latest studies have emphasized the importance of adipose tissue as a highly endocrine organ which releases a wide variety of biological active substances. In this context we have recently showed that adipose tissue exerts highly potent cardiodepressant activity with an acute effect directly on cardiomyocytes contraction, thus explaining the tight association between obesity and heart failure. Further experiments led to the assumption that the activity is a protein, but some well-known adipocyte-derived proteins could be excluded to be responsible for the effect on cardiomyocytes. In the present study we investigated the production/secretion of this adipocyte-derived negative inotropic activity in more detail.

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Authors and Affiliations

  1. Medical Clinic III, University of Dresden, Dresden, Germany

    Christiane Look & Valéria Lamounier-Zepter

  2. Max-Delbrueck-Center for Molecular Medicine and University Medicine Charité, Berlin, Germany

    Ingo Morano

Authors
  1. Christiane Look
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  2. Ingo Morano
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  3. Valéria Lamounier-Zepter
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Correspondence to Valéria Lamounier-Zepter.

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Look, C., Morano, I. & Lamounier-Zepter, V. Human adipocyte-derived factors directly inhibit cardiac contraction. J Muscle Res Cell Motil 29, 181–184 (2008). https://doi.org/10.1007/s10974-009-9172-2

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  • DOI: https://doi.org/10.1007/s10974-009-9172-2

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