Abstract
The enthalpies of vaporization/sublimation of 2-, 3- and 4-methyl-acetophenones and 2-, 3-, 4-cyano-acetophenones were derived from the vapor pressure temperature dependence measured with help of the gas saturation method. Enthalpies of fusion of 4-methyl-acetophenone and 2-, 3- and 4-cyano-acetophenone were measured by using DSC. The literature thermochemical data for methyl-, ethyl, cyano- and acetoxy-substituted acetophenones and new results were evaluated using structure–property correlations. The G* quantum chemical methods were validated for reliable estimation of the enthalpies of formation of substituted acetophenones in the gaseous state. The evaluated thermodynamic data were used to design the “centerpiece” method for the assessment of enthalpies of formation and enthalpies of vaporization of substituted benzenes.
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Introduction
Structure–property relationships belong to the basic principles of chemistry. Substituted benzenes are a remarkable model system for structure–property manifestation. The type and position of substituents on benzene ring significantly influence the physicochemical properties of the compound and the appropriate chemical, physical or biological effects. The quantification of these relationships in series of substituted benzenes has been a long-standing goal of our laboratory [1,2,3]. The aim of the present study is therefore to continue this research on series of acetophenones substituted with the methyl, ethyl, cyano and acetoxy groups.
The fundamental properties of these substituted benzenes: vapor pressures, enthalpies of formation, \(\Delta_{\text{f}} H_{\text{m}}^{\text{o}}\) (g, liq or cr), and phase transitions enthalpies: \(\Delta_{{{\text{cr}}}}^{\text{g}} H_{\text{m}}^{\text{o}}\) (sublimation), \(\Delta_{\text{l}}^{\text{g}} H_{\text{m}}^{\text{o}}\) (vaporization) and \(\Delta_{{{\text{cr}}}}^{\text{l}} H_{\text{m}}^{\text{o}}\) (fusion) derived in this work, as well as those from the literature and were validated and checked for internal consistency. The consistent enthalpic data sets for disubstituted benzenes were analyzed with help of a “centerpiece” approach [1,2,3] in order to quantify the energetics of substituent interactions on the benzene ring.
Experimental
Materials
The structural formulas of acetophenones substituted with the methyl, ethyl, cyano and acetoxy groups studied in this work are given in Fig. 1.
In this study, we used commercial samples of 95–99% purities as stated by manufacturer, see Table S1). The liquid compounds were additionally purified by vacuum distillation. The solids were re-sublimed at reduced pressure. Purities of samples were measured by a GC equipped with a capillary column. Only residual amounts of impurities (no more than 0.05%) were detected in the compounds examined by transpiration.
Experimental and computational methods
The vapor pressures of substituted acetophenones were determined by using the gas saturation method with a self-made setup [4, 5]. The glass beads covered with the sample were placed in the saturator. The system was exposed to the nitrogen stream at a precisely defined flow rate. Before leaving the saturator, the liquid–gas (or solid–gas) equilibrium was reached. The material transported out of the saturator within a certain time was trapped and quantified with help of gas chromatography. The vapor pressure, \(p_{i}\), at each saturation temperature, \(T_{i}\), was derived from the amount of sample collected in the cold trap using the ideal gas law:
with \(m_{\text{i}}\) = mass of the condensed sample; R = ideal gas constant; \(T_{\text{a}}\) = ambient temperature; V = gas-phase volume consisting of ni mole of compound in the nitrogen stream (of molar mass \(M_{\text{i}}\)) and \(n_{N2}\) moles of nitrogen; and \(P_{a}\) is atmospheric pressure.
The vapor pressures obtained from the gas saturation method are considered reliable within (1 to 3)% [4, 5]. The temperature dependence of vapor pressure was used for evaluation of sublimation/vaporization enthalpies. The error in sublimation/vaporization enthalpies is believed to be within ± (0.3–0.5) kJ mol−1 [4, 5].
Enthalpies of fusion of 4-methyl-acetophenone and 2-, 3- and 4-cyano-acetophenone were measured by using the Mettler Toledo DSC 823e equipped with Huber TC125MT. Details are published elsewhere [6]. The calibration of the DSC was carried out with indium. The deviation of the melting temperature, Tm, from that of the reference compound was not greater than 0.3 K. The enthalpy of fusion, agreed with the reference value better than 0.2 kJ mol−1. In order to obtain sufficient contact between the bottom of the pan and the sample, the pan was heated in the first DSC run at a rate of 10 K·min−1 to a temperature that was ~ 30 K above the known Tm and then at the same rate cooled to room temperature. The choice of heat rate is caused by the fact that this rate is a yardstick for many organic substances to carry our DSC measurements. The DSC measurements were repeated 3–4 times. All measurements were taken under nitrogen flow.
The quantum chemical calculations were carried out with the Gaussian 09 [7]. The preliminary search for the stable conformers was carried out initially using MM3 [8] and then by b3lyp/6-31 g(d,p) [9]. The energies E0 and enthalpies H298 of the most stable conformers were estimated with the high-level composite methods G3MP2 [10] and G4 [11]. The standard enthalpies of formation in the gas state of the compound of interest were calculated using H298 taken from the output of the Gaussian 09 file. Details of the calculation procedure have been given elsewhere [12].
Results and discussion
Vapor pressures of substituted acetophenones
The vapor pressures, \(p_{\text{i}}\), measured for methyl- and cyano-acetophenones by the gas saturation method were approximated using the equation:
In this equation: R = universal gas constant; \(p_{{{\text{ref}}}} = 1 {\text{Pa}}\); a and b are adjustable parameters; \(\Delta_{{{\text{cr}},{\text{l}}}}^{{\text{g}}} C_{\text{p},{\text{m}}}^{{\text{o}}}\) = difference between heat capacities \(C_{\text{p},{\text{m}}}^{\text{o}}\)(g) or \(C_{\text{p},{\text{m}}}^{\text{o}}\)(liq or cr) phases, respectively; and T0 = arbitrarily 298.15 K. Values \(\Delta_{{{\text{cr}},\,{\text{l}}}}^{\text{g}} C_{\text{p},{\text{m}}}^{\text{o}}\) are given in Table S2. They were estimated using a procedure suggested by Chickos and Acree [13] based on the standard molar heat capacities \(C_{\text{p},{\text{m}}}^{\text{o}}\)(cr) or \(C_{p,m}^{o}\)(liq). The absolute vapor pressures for methyl- and cyano-acetophenones are given in Table 1.
Absolute vapor pressure values of 2-methyl-acetophenone, 3-methyl-acetophenone, 2-cyano-acetophenone, 3-cyano-acetophenone and 4-cyano-acetophenone were not found in the literature. The temperature dependences of available vapor pressures for 4-methyl-acetophenone are shown in Fig. S1. The agreement of our new transpiration results with those from the Knudsen method [16] is poor. It should be noted, however, that the Knudsen method is normally used for measurements of very low pressures (usually below 1 Pa) over the solid samples. As a consequence, the disagreement observed could be attributed to the limitations specific for the Knudsen method. Vapor pressures derived for 4-methyl-acetophenone and 2-ethyl-acetophenone from the coefficients of Antoine equation given by Stephenson and Malanowski [17] are also questionable as neither the method nor the purity of the sample are available.
The very limited data on vapor pressures of ethyl-substituted acetophenones prompted us to collect experimental boiling temperatures at different pressures compiled by SciFinder [18]. The accuracy of these data is questionable as it comes from the distillation of a compound after its synthesis and not from special physicochemical studies. However, the numerous data on boiling temperatures at standard pressure, as well as at reduced pressures (see Table S3), provide at least a reliable level of the experimental vapor pressures and a reliable trend of the dependence of the vapor pressure with temperature. For example, in Fig. S2 for 2-ethylacetophenone, the boiling points at different pressures compiled by SciFinder are in fair agreement with the available data set from Stephenson and Malanowski [17]. In this work, we have systematically collected the data available for 2-, 3- and 4-ethylacetophenones in the SciFinder [18] for comparison (see Table S3). The comparisons of these results with those available from the literature are shown in Figs. S2–S4 (supporting information). From these comparisons, it was concluded that data from the static method of Khorevskaya et al. [19] for 3-ethyl- and 4-ethylacetophenone are most likely in error.
Vaporization/sublimation thermodynamics of substituted acetophenones
The experimental vapor pressures were used to estimate the enthalpies of vaporization/sublimation of substituted acetophenones according to equations:
The vaporization/sublimation entropies at temperatures T were estimated from the experimental p–T dependences:
with \(p^{{\text{o}}}\) = 0.1 MPa. Values of \(\Delta_{{\text{l},{\text{cr}}}}^{\text{g}} H_{\text{m}}^{\text{o}}\)(T) and \(\Delta_{{\text{l},{\text{cr}}}}^{\text{g}} S_{\text{m}}^{\text{o}}\)(T) are collected in Table 1. The algorithm for calculating the uncertainties in the enthalpies of vaporization/sublimation can be found elsewhere [14, 15]. These combined uncertainties include uncertainties in vapor pressure, uncertainties inherent in the experimental conditions of the gas saturation method and uncertainties due to adjustment to T = 298.15 K. The standard molar enthalpies of vaporization/sublimation of substituted acetophenones at T = 298.15 K, estimated using Eqs. 3 and 4 are given in Table 2.
Our new result for 2-methyl-acetophenone \(\Delta_{\text{l}}^{\text{g}} H_{\text{m}}^{\text{o}}\)(298.15 K) = 59.3 ± 0.4 kJ mol−1 agrees well with the value \(\Delta_{\text{l}}^{\text{g}} H_{\text{m}}^{\text{o}}\)(298.15 K) = 58.9 ± 0.9 kJ·mol−1, directly measured by Calvet calorimetry [20]. The enthalpy of vaporization for 4-methyl-acetophenone, \(\Delta_{\text{l}}^{\text{g}} H_{\text{m}}^{\text{o}}\)(298.15 K) = 60.7 ± 1.0 kJ·mol−1, measured directly by Calvet calorimetry [20], and the values obtained in this work from the vapor pressures temperature dependences [16, 17] are in very good accordance (see Table 2). The enthalpy of sublimation \(\Delta_{{{\text{cr}}}}^{\text{g}} H_{\text{m}}^{\text{o}}\)(298.15 K) = 97.1 ± 0.6 kJ·mol−1 of 3-cyano-acetophenone measured in this work by the gas saturation method is in fair accordance with the is \(\Delta_{{{\text{cr}}}}^{\text{g}} H_{\text{m}}^{\text{o}}\)(298.15 K) = 94.7 ± 1.5 kJ mol−1 measured by a Calvet calorimeter [22].
Vapor pressures over liquid and crystalline samples of 2-acetoxy-, 3-acetoxy- and 4-acetoxy-acetophenones, were systematically studied by combination of the static and Knudsen method just recently [22]. We approximated these experimental vapor pressures by Eq. (1) and estimated (see Table 2) the phase transition enthalpies according to Eqs. (3) and (4) with \(\Delta_{{{\text{cr}},{\text{l}}}}^{\text{g}} C_{\text{p},{\text{m}}}^{\text{o}}\)-values from Table S2. Table 2 obviously shows that the liquid–gas and the crystal–gas phase transitions for all three isomers are very consistent and these values were taken for thermochemical calculations in the current study.
Validation of experimental vaporization enthalpies
The limited amount of vaporization enthalpies available for substituted acetophenones and the inconsistency in vapor pressures observed for ethylacetophenones have required additional validation of our results.
Validation using normal boiling temperatures
Empirical correlations within series of similarly shaped series of compounds, e.g., correlation of vaporization enthalpies with boiling points, Tb, is a valuable option to establish the consistency of available experimental results [23]. The available literature data on Tb for substituted acetophenones [18, 24] were correlated with the \(\Delta_{\text{l}}^{\text{g}} H_{\text{m}}^{\text{o}}\)(298.15 K)-values evaluated in Table 3.
For the set of compounds collected in Table 3, the following linear correlation was estimated (in kJ mol−1):
Table 3 shows that the results derived from this correlation with the boiling temperatures agree well (within the uncertainties) with results measured with the gas saturation method. Thus, such close agreement indicates a successful way to validate the experimental \(\Delta_{\text{l}}^{\text{g}} H_{\text{m}}^{\text{o}}\)(298.15 K) data derived (see Table 1) using the gas saturation method. According to Table 3, the differences between estimated according to Eq. 7 and experimental values are mostly below 2 kJ·mol−1. Hence, the uncertainties of ± 1.5 kJ·mol−1 can be ascribed to estimates obtained with Eq. (7). We used Eq. (7) to estimate the questionable vaporization enthalpies of isomeric ethylacetophenones (see Table 3). The latter values were denoted by a symbol Tb and shown in Table 2 for comparison with results dived by other methods.
Validation with Kovats’s retention indices
Correlating the experimental \(\Delta_{\text{l}}^{\text{g}} H_{\text{m}}^{\text{o}}\)(298.15 K)-values of parent substances with their Kovats’s indices, Jx [30], is another way for establishing data consistency [23, 31]. The Kovats’s retention indices for substituted benzenes [31] were correlated with the \(\Delta_{\text{l}}^{\text{g}} H_{\text{m}}^{\text{o}}\). (298.15 K)-values evaluated in Table 2. The results are shown in Table 4.
The experimental \(\Delta_{{\text{l}}}^{{\text{g}}} H_{{\text{m}}}^{{\text{o}}}\)(298.15 K)-values show a linear correlation with Kovats’s indices in in a series of n-alcohols, n-alkanes, aliphatic ethers, alkylbenzenes, etc. [33]. Also, the \(\Delta_{\text{l}}^{\text{g}} H_{\text{m}}^{\text{o}}\)(298.15 K)-values of substituted benzenes (collected in Table 4) show a linear correlation with Jx-values:
The \(\Delta_{\text{l}}^{\text{g}} H_{\text{m}}^{\text{o}}\)(298.15 K)-values derived from the correlation with the Kovats’s indices (see Table 4) agree perfectly with values obtained by the gas saturation method. This agreement can be regarded as a complementary validation of our new experimental data given in Table 1. According to Table 4, the differences between Eq. 8 estimates and the experimental values are mainly below 1 kJ·mol−1. Therefore, the uncertainties of ± 0.7 kJ·mol−1 can be ascribed to estimates using Eq. (8). We also used Eq. (8) to calculate the questionable enthalpies of vaporization of the isomeric ethylacetophenones (see Table 4). The latter values were denoted by a symbol Jx and shown in Table 2 for comparison with results derived by other methods.
Consistency of solid–liquid, solid–gas and liquid–gas phase transitions
All cyano-acetophenones and all acetoxy-acetophenones are solids at room temperatures. We have collected in Table 5 the solid phase transition data available for these compounds.
The enthalpy of fusion of 4-methyl-acetophenone, \(\Delta_{{{\text{cr}}}}^{\text{l}} H_{\text{m}}^{\text{o}}\)(Tfus) = 14.3 ± 0.1 kJ·mol−1 at Tfus = 251.8 ± 0.1 K, was measured for the first time. A typical DSC curve of 4-methyl-acetophenone is shown in Fig. S5. The only fusion temperature available for comparison, Tfus = 208.7 K [35] is significantly lower than the value we obtained. Taking into account the absence of purity attestation for the sample measured by Timmermans [35], our result for the highly pure sample of 4-methyl-acetophenone (99.1 ± 0.1%) appears to be more reliable.
Melting temperatures, Tfus, and enthalpies of fusion,\(\Delta_{{{\text{cr}}}}^{\text{l}} H_{\text{m}}^{\text{o}}\)(Tfus), of 2-, 3- and 4-cyano-acetophenone were not found in the literature for comparison. The enthalpies of fusion and melting temperatures of 2-, 3- and 4-acetoxy-acetophenone (see Table 5) were taken from the literature [22]. According to common practice, the experimental,(Tfus)-values have to be adjusted to T = 298.15 K using Eq. (9) [13]:
The values of \(\Delta_{{{\text{cr}}}}^{\text{g}} C_{\text{p},{\text{m}}}^{\text{o}}\) and \(\Delta_{\text{l}}^{\text{g}} C_{\text{p},{\text{m}}}^{\text{o}}\) are listed in Table S2. The enthalpies of fusion, \(\Delta_{{{\text{cr}}}}^{{\text{l}}} H_{{\text{m}}}^{{\text{o}}}\)(298.15 K), estimated with Eq. (9) are given in Table 5. These values can now be used to establish consistency of the phase transitions for cyano-acetophenones and acetoxy-acetophenones collected in Table 2 as follows. Vaporization, fusion and sublimation enthalpies are related by Eq. (10):
when all enthalpies are adjusted to the common temperature T = 298.15 K.
For example, the vapor pressures of 4-cyano-acetophenone were deliberately measured (see Table 1) below and above the melting temperature using the gas saturation method. The sublimation enthalpy, \(\Delta_{\text{cr}}^{\text{g}} H_{\text{m}}^{\text{o}}\)(298.15 K) = 87.7 ± 0.7 kJ·mol−1, and the vaporization enthalpy, \(\Delta_{{\text{l}}}^{{\text{g}}} H_{{\text{m}}}^{{\text{o}}}\)(298.15 K) = 72.1 ± 0.4 kJ·mol−1, of 4-cyano-acetophenone are given in Table 1. According to Eq. (10) and together with the fusion enthalpy, \(\Delta_{{{\text{cr}}}}^{\text{l}} H_{\text{m}}^{\text{o}}\)(298.15 K) = 15.9 ± 0.4 kJ·mol−1, the “theoretical” vaporization enthalpy of 4-cyano-acetophenone was estimated to be \(\Delta_{\text{l}}^{\text{g}} H_{\text{m}}^{\text{o}}\)(298.15 K) = 87.7—15.9 = 71.8 ± 0.5 kJ·mol−1. The latter value is in excellent agreement with the experiment, demonstrating consistency of the phase transition data for this compound. In a similar way, the consistency of the data for other cyano-acetophenones and acetoxy-acetophenones was established (see calculations in Table 5 and the final values in Table 2).
Evaluation of available vaporization enthalpies
In order to ascertain the accuracy of the vaporization thermodynamics of the alkyl-substituted acetophenones, we applied three empirical methods (\(\Delta_{l}^{g} H_{m}^{o}\)(298.15 K)—Tb correlation), (\(\Delta_{\text{l}}^{\text{g}} H_{\text{m}}^{\text{o}}\)(298.15 K)—Jx correlation) and consistency of phase transitions. The experimental and “theoretical” vaporization enthalpies derived for each set of substituted acetophenones, are given in Table 2.
This table shows that for each substituted acetophenone agreement among available \(\Delta_{\text{l}}^{\text{g}} H_{\text{m}}^{\text{o}}\)(298.15 K) and \(\Delta_{{{\text{cr}}}}^{\text{g}} H_{\text{m}}^{\text{o}}\)(298.15 K) values, obtained in different ways is generally within the error bars. To improve the reliability, we calculated the weighted average (the uncertainty was used as a weighing factor) for each substituted acetophenone given in Table 2. These values are highlighted in bold and are recommended for thermochemical estimations and the general quantitative analysis of the results. For example, in our previous work [36,37,38,39,40,41,42], it was found that meta- and para-disubstituted benzenes have similar vaporization enthalpies values. ortho-disubstituted benzenes usually differ from those for meta- and para-disubstituted species. The size of the differences depends on the nature of the substituents. The general trend, however, is that the enthalpies of vaporization of the ortho-species are somewhat lower compared to meta- and para-substitution. The vaporization enthalpies of methyl, ethyl, cyano and acetoxy-acetophenones follow this general trend (see Table 2) and confirm the consistency of the data evaluated.
Standard molar enthalpies of formation
Very limited enthalpies of formation of substituted acetophenones are available in the literature. The \(\Delta_{\text{f}} H_{\text{m}}^{\text{o}}\)(298.15)-values of 2-methyl- and 4-methyl-acetophenone were measured by Amaral et al. [20] by the combustion calorimetry. Later, the enthalpy of formation of 3-cyano-acetophenone was measured in the same laboratory [21]. The numerical data available in the literature are summarized in Table 6.
In order to compensate for the lack of enthalpic data, the gas-phase formation enthalpies for methyl, ethyl, cyano and acetoxy-substituted acetophenones were estimated with help of quantum chemical methods.
Structures of substituted acetophenones were optimized with MM3 [8] and B3LYP/6-31 g(d,p) methods [9]. Energies of the most stable conformers for each isomer were calculated by using the composite G3MP2 [10] and G4 methods [11]. The H298 enthalpies of the most stable conformers of the substituted acetophenones estimated by the composite methods were converted into the theoretical enthalpies of formation using the experimental gas-phase standard molar enthalpies of formation, \(\Delta_{\text{f}} H_{\text{m}}^{\text{o}}\)(g, 298.15 K), of benzene, toluene, ethylbenzene, cyanobenzene, acetoxybenzene and acetophenone (see Table S4) using the following well-balanced reactions:
The theoretical enthalpies of formation of the substituted acetophenones calculated by G3MP2 and G4 methods are summarized in Table 7. Using two methods simultaneously helps to avoid possible systematic errors caused by the calculations.
The theoretical values of \(\Delta_{\text{f}} H_{\text{m}}^{\text{o}}\)(g, 298.15 K) as calculated by the G3MP2 and the G4 method are very close for each compound (see Table 7). Therefore, we calculated the weighted average value for each substituted acetophenone in Table 7 and designated it as the theoretical value, \(\Delta_{\text{f}} H_{\text{m}}^{\text{o}}\)(g, 298.15 K)theor, for comparison with the experimental values, \(\Delta_{\text{f}} H_{\text{m}}^{\text{o}}\)(g, 298.15 K)exp, compiled in Table 6. Comparison of column 5 with column 4 in Table 6 shows good agreement between the theoretical and experimental \(\Delta_{\text{f}} H_{\text{m}}^{\text{o}}\)(g, 298.15 K)-values for 2-methyl-acetophenone, 4-methyl-acetophenone and 3-cyano-acetophenone. Such good agreement can be viewed as a manifestation of internal consistency of experimental results evaluated in Table 6. These new evaluated results are recommended for thermochemical calculations, e.g., of the liquid-phase enthalpies of formation \(\Delta_{\text{f}} H_{\text{m}}^{\text{o}}\)(liq, 298.15 K) according to the general equation:
Indeed, the reliable theoretical enthalpies of formation \(\Delta_{\text{f}} H_{\text{m}}^{\text{o}}\)(g)theor given in Table 7 have compensated for the lack of required data for Eq. (15) data. Together with the reliable enthalpies of vaporization evaluated in Table 2, these results can therefore be used to calculate the theoretical liquid-phase enthalpies of formation (see Table 8, column 4).
Comparison of column 5 with column 4 in Table 8 shows agreement between the theoretical and experimental \(\Delta_{\text{f}} H_{\text{m}}^{\text{o}}\)(liq, 298.15 K)-values available for 2-methyl-acetophenone, 4-methyl-acetophenone and 3-cyano-acetophenone. These results for the enthalpies of formation in the liquid phase of substituted acetophenones can now be recommended for thermochemical calculations.
Development of a “centerpiece” approach for substituted benzenes
The main idea of this group additivity-based approach is to select an appropriate "centerpiece" molecule (e.g., benzene, acetophenone or toluene) with well-known thermochemical properties. Different substituents can be appended to the “centerpiece” in various positions. The enthalpic contribution for each appended substituent is quantified as the differences between the enthalpy of the benzene and enthalpy of the substituted benzene. The consistent sets of thermochemical data on \(\Delta_{\text{f}} H_{\text{m}}^{\text{o}}\)(298.15 K), \(\Delta_{\text{f}} H_{\text{m}}^{\text{o}}\)(g, 298.15 K) and \(\Delta_{\text{f}} H_{\text{m}}^{\text{o}}\)(liq, 298.15 K) evaluated in this work have been used for developing a “centerpiece” group contribution approach that is particularly suitable for aromatic compounds. Using this idea, the contributions ΔH(H → CH3), ΔH(H → C2H5), ΔH(H → COCH3), ΔH(H → CN) and ΔH(H → OCOCH3) were derived (see Table 9) using data for toluene, ethylbenzene, acetophenone, cyanobenzene, acetoxybenzene and benzene compiled in Table S4. These enthalpic contributions ΔH(H → R) can be further used to build a framework of arbitrary structured substituted benzene derivatives starting from the “centerpieces” (e.g., acetophenone in this work). In terms of energy, this framework needs to be extended to include interactions between the substituents on the benzene ring.
The enthalpic contributions for mutual pairwise interactions of substituents are specific for the ortho-, meta- and para-positions of substituents attached to the benzene ring. The usual method for quantifying these interactions are reaction enthalpies, \(\Delta_{\text{r}} H_{\text{m}}^{\text{o}}\)(g or liq), according to Eqs. 11, 12, 13, 14, written in reverse (e.g., for Eq. 11 it is written as follows: toluene + acetophenone = x-methyl-acetophenone + benzene). This approach also applies to the estimation of contributions to the enthalpy of vaporization. The pairwise interactions for all three thermodynamic properties derived in this way are given in Table 9.
The intensity of substituent interactions quantitatively, strongly depends on the type of ortho-, meta- or para-pairs. Let us consider the strength of pairwise interaction in terms of \(\Delta_{\text{f}} H_{\text{m}}^{\text{o}}\). (g). Table 9 shows that all ortho-substituted benzenes exhibit a strong destabilization at the level of 10–15 kJ mol−1 on their enthalpies of formation (g or liq) due to interactions of bulky groups placed in close proximity. Usually, the meta- and para-interactions of substituents are less intensivcompared to ortho-interactions. This trend also applies to the interactions of the substituents examined in this work. The moderate stabilization or destabilization at the level from 2 to 5 kJ·mol−1 (see Table 9) is observed for the meta- and para-isomers. The pairwise interaction in terms of \(\Delta_{\text{f}} H_{\text{m}}^{\text{o}}\) (liq) follow the similar trends as for the gaseous species (see Table 9).
The understanding of pairwise interactions with respect to \(\Delta_{\text{l}}^{\text{g}} H_{\text{m}}^{\text{o}}\) is rather limited, since they related to the structuring of the liquid. However, for practical calculations, these contributions collected in Table 9, column 2, have to be used as empirical constants in order to get the correct enthalpies of vaporization.
Conclusions
Absolute vapor pressures and enthalpies of vaporization/sublimation of methyl- and cyano-acetophenones have been measured using the transpiration method. Data available from the literature on enthalpy of vaporization values for ethyl- and acetoxy-acetophenones were collected and analyzed. The enthalpies of fusion of 4-methyl-acetophenone, 2-, 3- and 4-cyano-acetophenones were measured using the DSC method. The available experimental data were collected from the literature. The experimental results on the liquid–gas, solid–gas and solid–liquid phase transitions were evaluated using empirical correlations based on boiling points and retention indices. The high-level quantum chemical methods were validated with help of reliable experimental results and the gas-phase enthalpies of the formation of substituted acetophenones were estimated. The set of thermodynamic data was evaluated using empirical and quantum chemical methods. These data were used to design and refine the “centerpiece” method for predicting vaporization and formation of disubstituted benzenes. The pairwise interactions of substituents on a benzene ring obtained in this work are expected to be transferable for estimation of properties of poly-substituted benzenes.
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Acknowledgements
This work has been supported by the German Science Foundation (DFG) in the frame of the priority program SPP 1807 “Control of London Dispersion Interactions in Molecular Chemistry,” grant VE 265-9/2. IVA acknowledges financial support from DFG, grant VE 265/12-1 “Glycolysis: thermodynamics and pathway predictions.”
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Andreeva, I.V., Verevkin, S.P. Thermochemistry of substituted benzenes: acetophenones with methyl, ethyl, cyano and acetoxy substituents. J Therm Anal Calorim 147, 11401–11415 (2022). https://doi.org/10.1007/s10973-022-11326-3
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DOI: https://doi.org/10.1007/s10973-022-11326-3