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Thermal characterization of the bromopride recrystallized from different solvents and at different temperature conditions

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Abstract

Polymorphism is the ability of a substance to crystallize into different crystalline states. Different polymorphs vary according to their physical and chemical properties, and therefore, the presence of different crystalline forms of a drug may change some physicochemical properties of certain medicines. The goal of this work was to detect polymorphic forms of a compound used as a drug, bromopride. For the purpose of this study, recrystallizations were carried out from different solvents and at distinct temperatures, with the aim of obtaining different crystalline forms, which were characterized by dynamic thermal analysis (DTA) and X-ray powder diffraction. The samples obtained through recrystallization in different temperature conditions and solvents showed peculiar DTA curves and diffractograms profiles, indicating the presence of crystalline forms distinct from each other.

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Acknowledgements

The authors are grateful to Professor Dr. Costa of State University of Maringa for XRPD analysis. J. Cortez is grateful to CAPES for postdoctoral fellowship.

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Authors and Affiliations

  1. Technical Course in Chemistry, Technological Federal University of Parana State-UTFPR, Av. Brasil 4232, Medianeira, PR, 8584000, Brazil

    Heloise Carrer

  2. Master’s Program in Environmental Technologies, Technological Federal University of Parana State-UTFPR, Av. Brasil 4232, Medianeira, PR, 8584000, Brazil

    Juliana Cortez, Laercio Mantovani Frare, Michelle Budke Costa & Paulo Rodrigo Stival Bittencourt

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  1. Heloise Carrer
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  2. Juliana Cortez
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  3. Laercio Mantovani Frare
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  4. Michelle Budke Costa
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  5. Paulo Rodrigo Stival Bittencourt
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Correspondence to Paulo Rodrigo Stival Bittencourt.

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Carrer, H., Cortez, J., Frare, L.M. et al. Thermal characterization of the bromopride recrystallized from different solvents and at different temperature conditions. J Therm Anal Calorim 123, 927–931 (2016). https://doi.org/10.1007/s10973-015-5027-9

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  • DOI: https://doi.org/10.1007/s10973-015-5027-9

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