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Thermal behavior of furosemide

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Abstract

Data from theoretical, thermal, and spectroscopic methods were compared in order to map a possible mechanism for the thermal decomposition of furosemide, a diuretic compound, in solid state. TG/DTG curves suggested a two-stage decomposition process. The first product of decomposition is water (m/z = 18), released due to a dimerization resulting in the formation of an amide. Then carbon dioxide (m/z = 44), nitroxide (m/z = 30), and 2-methyl-furanyl ion (m/z = 81) are released in the second stage. The chlorine substituted benzene ring, due to the double bond conjugated system, being the last fraction to decompose. Theoretical calculations presented are in agreement with experimental results.

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Acknowledgements

Authors are also grateful to Dr. Samuel Pitta (UFRJ, Brazil), for his contribution and discussions regarding theoretical calculations, as well as to Brazilian Agencies CAPES and FAPESP.

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Author notes

  1. Felipe Silva Semaan

    Present address: Departamento de Química Analítica da Universidade Federal Fluminense (GQA-UFF), Outeiro São João Batista, s/n, Campus do Valonguinho, Niterói, RJ, Brazil

Authors and Affiliations

  1. Instituto de Química de São Carlos—USP, Av. Trab. São-carlense 400, CP 780, São Carlos, SP, CEP 13560-970, Brazil

    Rita de Cássia da Silva, Felipe Silva Semaan & Eder Tadeu Gomes Cavalheiro

  2. Budapest University of Technology and Economics, Budapest, P.O. Box 91, 1521, Hungary

    Csaba Novák

Authors
  1. Rita de Cássia da Silva
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  2. Felipe Silva Semaan
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  3. Csaba Novák
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  4. Eder Tadeu Gomes Cavalheiro
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Correspondence to Eder Tadeu Gomes Cavalheiro.

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de Cássia da Silva, R., Semaan, F.S., Novák, C. et al. Thermal behavior of furosemide. J Therm Anal Calorim 111, 1933–1937 (2013). https://doi.org/10.1007/s10973-011-2058-8

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  • DOI: https://doi.org/10.1007/s10973-011-2058-8

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