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Thermal kinetic studies on the decompositions of cefuroxime lysine in different atmospheres and heating rates

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Abstract

The thermal decomposition of a new antibiotic agent, cefuroxime lysine, was investigated by thermogravimetry analysis/derivative thermogravimetry and differential scanning calorimetry (DSC) methods in anoxic and oxidative environments. The influence of heating rates (including 5, 10, 15, and 20 °C/min) on the thermal behavior of cefuroxime lysine was revealed. By the methods of Kissinger and Flynn–Wall–Ozawa, the thermal kinetic parameters of activation energy and pre-exponential factor for the exothermic processes under non-isothermal conditions were calculated using the analysis of corresponding DSC curves.

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References

  1. Ocakoglu K, Emen FM. Thermal analysis of cis-(dithiocyanato)(1,10-phenanthroline-5,6-dione) (4,4′-dicarboxy-2,2′-bipyridyl)ruthenium(II)photosensitizer. J Therm Anal Calorim. 2011;104:1017–22.

    Article  CAS  Google Scholar 

  2. Janković B, Mentus S. Thermal stability and nonisothermal kinetics of Folnak degradation process. Drug Dev Ind Pharm. 2010;36:980–2.

    Article  Google Scholar 

  3. de Oliveira HP, Rieumont J, Nogueiras C, Souza D, Sánchez R. Thermal degradation behavior of a carboxylic acid-terminated amphiphilic block copolymer poly(ethylene)-b-poly(ethylene oxide). J Therm Anal Calorim. 2011;103:443–51.

    Article  CAS  Google Scholar 

  4. Wang XJ, You JZ. Mechanism and kinetics of thermal decomposition of lamivudine. J Shenyang Pharm Univ. 2010;27:610–4.

    CAS  Google Scholar 

  5. Wang F, Zhou L, Zhou JH, Li G. Thermoanalysis studies on millrinone. Chin J Pharm Anal. 2009;29:253.

    CAS  Google Scholar 

  6. Kissinger HE. Reaction kinetics in differential thermal analysis. Anal Chem. 1957;29:1702–6.

    Article  CAS  Google Scholar 

  7. Ozawa T. A new method of analyzing thermogravimetric data. Bull Chem Soc Jpn. 1965;38:1881–6.

    Article  CAS  Google Scholar 

  8. Flynn JH, Wall LA. A quick, direct method for the determination of activation energy from thermogravimetric data. Polym Lett. 1966;4:323–8.

    Article  CAS  Google Scholar 

  9. Liu CY, Yu J, Sun XH, Zhang J, He JS. Thermal degradation studies of cyclic olefin copolymers. Polym Degrad Stab. 2003;81:197–205.

    Article  CAS  Google Scholar 

  10. Wilbum FW. The determination of kinetic parameters from DTG curves’s fact or fiction? Thermochim Acta. 1999;77:340–1.

    Google Scholar 

  11. Straszko J, Humienik MO, Mozejko J. Kinetics of thermal decomposition of ZnSO4·7H2O. Thermochim Acta. 1997;292:145–50.

    Article  CAS  Google Scholar 

  12. Humienik MO, Mozejko J. Thermodynamic functions of activated complexes created in thermal decomposition processes of sulphates. Thermochim Acta. 2000;344:73–9.

    Article  Google Scholar 

  13. Han X, Sun YL, Wang TF, Lin ZK, Li SF, Zhao FQ, Liu ZR, Yi JH, Ren XN. Thermal decomposition of ammonium perchlorate based mixture with fullerenes. J Therm Anal Calorim. 2008;91:551–7.

    Article  CAS  Google Scholar 

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Acknowledgements

The authors thank Prof. Karl Tsim of Hong Kong University of Science and Technology for his comment on this manuscript. This study was supported by the National Key Scientific Project for New Drug Discovery and Development (No. 2009ZX09301-012).

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Authors and Affiliations

  1. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China

    Longshan Zhao, Qing Li, Yan Cui, Jie Wang, Shanshan Xu, Xiaohui Chen & Kaishun Bi

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  1. Longshan Zhao
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  2. Qing Li
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  3. Yan Cui
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  4. Jie Wang
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  5. Shanshan Xu
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  6. Xiaohui Chen
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  7. Kaishun Bi
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Correspondence to Kaishun Bi.

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Zhao, L., Li, Q., Cui, Y. et al. Thermal kinetic studies on the decompositions of cefuroxime lysine in different atmospheres and heating rates. J Therm Anal Calorim 108, 269–273 (2012). https://doi.org/10.1007/s10973-011-1833-x

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  • DOI: https://doi.org/10.1007/s10973-011-1833-x

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