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Differential scanning calorimetry (DSC) analysis of human plasma in melanoma patients with or without regional lymph node metastases

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Abstract

Melanoma malignum (MM) is a common type of skin cancer, and its incidence is increasing in the general population. We aimed to detect blood plasma components with differential scanning calorimetry (DSC) in 15 white adult MM patients, who had histopathologically diagnosed, operable cutaneous MM without any distant metastases. We observed that thermal changes (second T m , calorimetric enthalpy) in blood plasma showed correlation with tumor thickness and the extent of regional invasion. Further studies are needed to elucidate these relationships, but our preliminary work has provided DSC should be a new tool for the early diagnosis and monitoring of MM patients.

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Acknowledgements

This work was supported by grants OTKA C272 (for D.L.), OTKA PD77474, and PTE AOK Research Grant 114-603/2009(for A.F.).

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Authors and Affiliations

  1. Department of Dermatology, Venereology and Oncodermatology, Medical School, University of Pécs, Kodály Z. str. 20, Pecs, 7624, Hungary

    Tamás Fekecs

  2. Surgery Clinic, Medical School, University of Pécs, Ifjúság str. 13, Pecs, 7624, Hungary

    István Zapf

  3. Department of Surgical Research and Techniques, Medical School, University of Pécs, Kodály Z str. 20, Pecs, 7624, Hungary

    Andrea Ferencz

  4. Institute of Biophysics, Faculty of Medicine, Medical School, University of Pécs, Szigeti str. 12, Pecs, 7624, Hungary

    Dénes Lőrinczy

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  1. Tamás Fekecs
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  2. István Zapf
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  3. Andrea Ferencz
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  4. Dénes Lőrinczy
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Correspondence to Dénes Lőrinczy.

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Fekecs, T., Zapf, I., Ferencz, A. et al. Differential scanning calorimetry (DSC) analysis of human plasma in melanoma patients with or without regional lymph node metastases. J Therm Anal Calorim 108, 149–152 (2012). https://doi.org/10.1007/s10973-011-1800-6

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  • DOI: https://doi.org/10.1007/s10973-011-1800-6

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