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Thermal characterization of lovastatin in pharmaceutical formulations

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Abstract

Thermogravimetry (TG) and differential scanning calorimetry (DSC) are useful techniques that have been successfully applied in the pharmaceutical industry to reveal important information regarding the physicochemical properties of drug and excipient molecules such as polymorphism, stability, purity, and formulation compatibility among others. In this study, lovastatin was studied by TG, DSC, and other techniques such as Fourier transform infrared spectroscopy, optical microscopy, X-ray diffraction, chromatography, and mass spectrometry. Lovastatin showed melting point at 445 K and thermal stability up to 535 K. It presented morphological polymorphism, which in the drug has the same unit cell, but with different crystal habits. Preservative excipient butylhydroxyanisole (BHA) causes amorphization of lovastatin crystallites and, therefore is incompatible with lovastatin. Degradation by hydrolysis was observed under neutral, acid, and basic conditions. The active degradation product, lovastatin hydroxyacid, was obtained after neutral and basic hydrolysis.

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Acknowledgements

FAPES, CNPq, and FAPEMIG are acknowledged for financial support and Laboratório Teuto Brasileiro for the raw materials donation.

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Authors and Affiliations

  1. Departamento de Química, Universidade Federal de Minas Gerais, Av. Pres. Antônio Carlos, 6627, Belo Horizonte, MG, 31270-901, Brazil

    M. I. Yoshida, E. C. L. Gomes & W. N. Mussel

  2. Centro Universitário Norte do Espírito Santo, UFES, Rodovia BR 101 Norte, km 60, Bairro Litorâneo, Sao Mateus, ES, 29932-540, Brazil

    M. A. Oliveira

  3. Departamento de Medicamento, Faculdade de Farmácia, Universidade Federal da Bahia, R. Barão de Jeremoabo, SN, Campus Ondina, Salvador, BA, 40170-115, Brazil

    W. V. Castro

  4. Departamento de Produtos Farmacêuticos, Universidade Federal de Minas Gerais, Av. Pres. Antônio Carlos, 6627, Belo Horizonte, MG, 31270-901, Brazil

    C. D. V. Soares

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  1. M. I. Yoshida
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  2. M. A. Oliveira
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  3. E. C. L. Gomes
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  4. W. N. Mussel
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Correspondence to M. I. Yoshida.

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Yoshida, M.I., Oliveira, M.A., Gomes, E.C.L. et al. Thermal characterization of lovastatin in pharmaceutical formulations. J Therm Anal Calorim 106, 657–664 (2011). https://doi.org/10.1007/s10973-011-1510-0

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