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Preparation of the Ca–diclofenac complex in solid state

Study of the thermal behavior of the dehydration, transition phase and decomposition

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Abstract

The Ca–diclofenac compound was prepared. Thermogravimetry (TG), derivative thermogravimetry (DTG), differential scanning calorimetry (DSC), X-ray diffraction powder patterns, and microscopy analysis were used to characterize this compound. Details concerning the stages of dehydration, transition phase, and thermal decomposition as well as data of the kinetic parameters of these stages have been described here. The kinetic study of these stages was evaluated from several heating rates with a sample mass of 2 and 5 mg in open crucibles under nitrogen atmosphere. The obtained data were evaluated with the isoconversional kinetic method, where the value of activation energy (E a/kJ mol−1) was evaluated in function of the conversion degree (α). The results show that this compound is hygroscopic. The obtained data lead to a dependence on the sample mass, which results in two kinetic behavior patterns.

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Acknowledgements

We express our deepest gratitude to CAPES Foundation, Brazil, for financial support, and IPT—Instituto de Pesquisas Tecnológicas do Estado de São Paulo for TG curves.

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Authors and Affiliations

  1. Instituto de Biociências, Letras e Ciências Exatas, Departamento de Química, Unesp, Univ. Estadual Paulista, São José do Rio Preto, SP, Brazil

    Marcelo Kobelnik

  2. Centro Universitário do Norte Paulista, UNORP, São José do Rio Preto, SP, Brazil

    Marcelo Kobelnik

  3. Instituto de Química de Araraquara, Unesp, Univ Estadual Paulista, C.P. 355, 14800-900, Araraquara, SP, Brazil

    Douglas Lopes Cassimiro, Clóvis Augusto Ribeiro, Diógenes dos Santos Dias & Marisa Spirandeli Crespi

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  1. Marcelo Kobelnik
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  2. Douglas Lopes Cassimiro
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  3. Clóvis Augusto Ribeiro
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  4. Diógenes dos Santos Dias
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  5. Marisa Spirandeli Crespi
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Correspondence to Marcelo Kobelnik.

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Kobelnik, M., Cassimiro, D.L., Ribeiro, C.A. et al. Preparation of the Ca–diclofenac complex in solid state. J Therm Anal Calorim 102, 1167–1173 (2010). https://doi.org/10.1007/s10973-010-0787-8

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  • DOI: https://doi.org/10.1007/s10973-010-0787-8

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