Skip to main content
SpringerLink
Log in

Microcalorimetric studies on the antimicrobial actions of different cephalosporins

  • Published:
Journal of Thermal Analysis and Calorimetry Aims and scope Submit manuscript

Abstract

Microcalorimetry was applied to study the effect of cephalosporins (cefazolin sodium and cefonicid sodium) on the E. coli growth. The microbial activity was recorded as power-time curves through an ampoule method with a TAM Air Isothermal Microcalorimeter at 37°C. The parameters such as the growth rate constant (k), inhibitory ratio (I), the maximum power output (P m) and the time corresponding to the maximum power output (t m) were calculated. The change tendencies of k, with the increasing of concentration (C) of the two cephalosporins, are similar which show that cefazolin sodium and cefonicid sodium have the same inhibitory mechanism. The experimental results reveal that cefonicid sodium has a stronger antibacterial activity towards E. coli than that of cefazolin sodium and this was coincide with the clinical manifestations.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. K. A. Caprile, J. Vet. Pharmacol. Ther., 11 (1988) 1.

    Article  CAS  Google Scholar 

  2. W. Christ, Infection, 19 (1991) S244.

    Article  CAS  Google Scholar 

  3. A. Chaudhury, Indian J. Med. Microbiol., 21 (2003) 52.

    CAS  Google Scholar 

  4. G. Opalchenova and G. N. Kalinkova, Int. J. Pharm., 189 (1999) 235.

    Article  CAS  Google Scholar 

  5. E. S. Park, M. Maniar and J. C. Shah, J. Controlled Release, 52 (1998) 179.

    Article  CAS  Google Scholar 

  6. A. Radi, T. Wahdan and N. A. El-Ghany, J. Pharm. Biomed. Anal., 31 (2003) 1041.

    Article  CAS  Google Scholar 

  7. K. L. Heim-Duthoy, G. L. Peltier, D. R. Guay and G. R. Matzke, Antimicrob. Agents Chemother., 32 (1988) 485.

    CAS  Google Scholar 

  8. M. J. Koenigbauer, Pharmaceut. Res., 11 (1994) 777.

    Article  CAS  Google Scholar 

  9. F. Xu, L. X. Sun, Z. C. Tan, J. G. Liang, C. G. Song and T. Zhang, 4th Internationanl and 6th Japan-China Joint Symposium on Calorimetry and Thermal Analysis, Fukuoka, Japan 2005, p. 170.

  10. L. N. Yang, F. Xu, L. X. Sun, Z. C. Tan, H. D. Tan, Z. B. Zhao and J. G. Liang, J. Therm. Anal. Cal., 85 (2006) 807.

    Article  CAS  Google Scholar 

  11. A. E. Beezer, J. C. Mitchell, R. M. Colegate, D. J. Scally, L. J. Twyman and R. J. Willson, Thermochim. Acta, 250 (1995) 277.

    Article  CAS  Google Scholar 

  12. N. R. Lisardo, J. A. R. Anon, J. P. Castineiras and O. N. Fernandez, Soil Biol. Biochem., 38 (2006) 115.

    Article  Google Scholar 

  13. J. C. Zhu, C. H. Li, Y. Liu, Z. H. Zhang, A. X. Hou and S. S. Qu, J. Therm. Anal. Cal., 83 (2006) 181.

    Article  CAS  Google Scholar 

  14. R. Zhao, Y. Liu, Z. X. Xie, P. Shen and S. S. Qu, J. Biochem. Methods, 46 (2000) 1.

    Article  CAS  Google Scholar 

  15. C. Zeng, J. C. Zhu, Y. Liu, Y. Yang, J. Y. Zhu, Y. P. Huang and P. Shen, J. Therm. Anal. Cal., 84 (2006) 625.

    Article  CAS  Google Scholar 

  16. J. Ma, W. T. Qi, L. N. Yang, W. T. Yu, Y. B. Xie, W. Wang, X. J. Ma, F. Xu and L. X. Sun, J. Microbiol. Methods, 68 (2007) 172.

    Article  CAS  Google Scholar 

  17. H. K. Koblish, S. Y. Zhao et al, Mol. Cancer Ther., 5 (2006) 160.

    Article  CAS  Google Scholar 

  18. H. Aki, M. Goto, M. Kai and M. Yamamoto, J. Therm. Anal. Cal., 57 (1999) 361.

    Article  CAS  Google Scholar 

  19. A. G. Prado and C. Airoldi, Pest Manage. Sci., 57 (2001) 640.

    Article  CAS  Google Scholar 

  20. F. E. Runge and R. Heger, J. Agric. Food Chem., 48 (2000) 47.

    Article  CAS  Google Scholar 

  21. J. Rodríguez-Añón, J. Proupín-Castiñeiras, M. Villanueva-López and O. Núñez-Fernández, J. Therm. Anal. Cal., 87 (2007) 15.

    Article  Google Scholar 

  22. L. N. Yang, S. J. Qiu, F. Xu, L. X. Sun, Z. B. Zhao, J. G. Liang and C. G. Song, J. Therm. Anal. Cal., 89 (2007) 875.

    Article  CAS  Google Scholar 

  23. I. Wadsö, Thermochim. Acta, 394 (2002) 305.

    Article  Google Scholar 

  24. C. L. Xie, H. K. Tang and S. S. Qu, Thermochim. Acta, 123 (1988) 33.

    Article  Google Scholar 

  25. A. Garedew, E. Schmolz and I. Lamprecht, Thermochim. Acta, 422 (2004) 115.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Materials and Thermochemistry Laboratory, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, 116023, P.R. China

    L. N. Yang, F. Xu & L. X. Sun

  2. Graduate School of the Chinese Academy of Sciences, Beijing, 100049, P.R. China

    L. N. Yang

  3. Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, 116023, P.R. China

    Z. B. Zhao

  4. Dalian Institute of Drug Detection, Dalian, 116021, P.R. China

    C. G. Song

Authors
  1. L. N. Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. L. X. Sun
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Z. B. Zhao
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. C. G. Song
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to F. Xu.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yang, L.N., Xu, F., Sun, L.X. et al. Microcalorimetric studies on the antimicrobial actions of different cephalosporins. J Therm Anal Calorim 93, 417–421 (2008). https://doi.org/10.1007/s10973-007-8680-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10973-007-8680-9

Keywords

Search

Navigation