Skip to main content

Advertisement

SpringerLink
Log in

Comparison of polyethylene glycol effect on hydroxyapatite morphology produced into different methods: sol–gel and precipitation

  • Original Paper
  • Published:
Journal of Sol-Gel Science and Technology Aims and scope Submit manuscript

Abstract

Hydroxyapatite (HA) can be used as a bioceramic due to its bioactivity and osteoconductive properties. It is clear that the morphology of HA crystal affects on its specifications such as surface and bioactivity. Because of importance of morphology, in the current research nano-sized HA particles were produced using sol–gel and precipitation methods, and to change the morphology, polyethylene glycol (PEG) was used as an organic modifier. The produced samples were characterized using X-ray powder diffraction (XRD) and scanning electron microscopy and transmission electron microscopy. The results of XRD patterns show that the pure HA can be produced using two methods. Microscopic evaluations prove that the presence of PEG has a significant effect on HA morphology. Indeed, PEG changes the morphology of HA produced by precipitation method to irregular, whereas in sol–gel method its shape leads toward fibrous with high aspect ratio. The exact reason of this variation can be attributed to the difference in mechanism of HA growth in two methods.

Graphical Abstract

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

References

  1. Dorozhkin SV (2010) Nanosized and nanocrystalline calcium orthophosphates. Acta Biomater 6:715–734

    Article  Google Scholar 

  2. Kalita SJ, Bhardwaj A, Bhatt HA (2007) Nanocrystalline calcium phosphate ceramics in biomedical engineering. Mater Sci Eng 27:441–449

    Article  Google Scholar 

  3. Eslami H, Solati-Hashjin M, Tahriri M (2009) The comparison of powder characteristics and physicochemical mechanical and biological properties between nanostructure ceramics of hydroxyapatite and fluoridated hydroxyapatite. Mater Sci Eng 29:1387–1398

    Article  Google Scholar 

  4. Wang P, Gong C, Jiang X, Wang K (2010) Effects of synthesis conditions on the morphology of hydroxyapatite nanoparticles produced by wet chemical process. Powder Technol 203:315–321

    Article  Google Scholar 

  5. Moszer N, Salz U (2007) Recent developments of new components for dental adhesives and composites. Macromol Mater Eng 292:245–271

    Article  Google Scholar 

  6. Zhang J, Zhan X, Wen X (2009) Effects of ultrasonic and dispersants on shape and composition of hydroxyapatite by reflux method. Inorg Mater 45:1362–1365

    Article  Google Scholar 

  7. Zhang C, Yang J, Quan Z, Yang P, Li C, Hou Z, Lin J (2009) Hydroxyapatite nano- and microcrystals with multiform morphologies: controllable synthesis and luminescence properties. Cryst Growth Des 9(6):2725–2733

  8. Nayak S, Satpati B (2010) Facile synthesis of nanostructured hydroxyapatite—titania bio-implant scaffolds with different morphologies: their bioactivity and corrosion behavior. J Mater Chem 20:4949–4954

    Article  Google Scholar 

  9. Salarian M, Solati-Hashemian M (2009) Surfactant-assisted synthesis and characterization of hydroxyapatite nanorods under hydrothermal conditions. Mater Sci-Pol 27(4):961–971

    Google Scholar 

  10. Zhang Y (2008) A mild and efficient biomimetic synthesis of rodlike hydroxyapatite particles with a high aspect ratio using polyvinylpyrrolidone as capping agent. Cryst Growth Des 8(7):2101–2107

    Article  Google Scholar 

  11. Alexeev VL, Kelberg EA, Evmenenko GA (2000) Improvement of the mechanical properties of chitosan films by the addition of poly(ethylene oxide). Polym Eng Sci 40:1211–1215

    Article  Google Scholar 

  12. Clavaguera N, Saurina J, Lheritier M (1997) Eutectic mixtures for pharmaceutical applications: a thermodynamic and kinetic study. Thermochim Acta 290:173–180

    Article  Google Scholar 

  13. Zhang S, Gonsalves KE (1997) Preparation and characterization of thermally stable nano hydroxyapatite. J Mater Sci Mater Med 8:25–28

    Article  Google Scholar 

  14. Azzaoui K, Lamhamdi A, Mejdoubi E, Berrabah M, Elidrissi A, Hammouti B, Zaoui S, Yahyaoui R (2013) Synthesis of nanostructured hydroxyapatite in presence of polyethylene glycol 1000. J Chem Pharm Res 5(12):1209–1216

    Google Scholar 

  15. Rogel MR (2006) Effects of hydroxyapatite crystal morphology on osteoblast-like cell response. Ph.D. thesis, University of Notre Dame

  16. Koutsoukos PG, Nancollas GH (1981) The morphology of hydroxyapatite crystals grown in aqueous solution at 37°C. J Cryst Growth 55(2):369–375

    Article  Google Scholar 

  17. Joseph R, McGregor WJ, Martyn MT, Tanner KE, Coates PD (2002) Effect of hydroxyapatite morphology/surface area on the rheology and processability of hydroxyapatite filled polyethylene composites. Biomaterials 23(21):295–302

    Article  Google Scholar 

  18. Sato K, Hotta Y, Nagaoka T, Yasuoka M, Wa-tari K (2006) Agglomeration control of hydroxyapatite nano-crystals grown in phase-separated microenvironments. J Mater Sci 41(17):5424–5428

    Article  Google Scholar 

  19. Brundavanam RK, Jiang ZT, Chapman P, Lê XT, Mondinod N, Fawcett D, Poinem GEJ (2011) Effect of dilute gelatine on the ultrasonic thermally assisted synthesis of nano hydroxyapatite. Ultrason Sonochem 18(3):697–703

    Article  Google Scholar 

  20. Qiu C, Xiao X (2008) Biomimetic synthesis of spherical nano-hydroxyapatite in the presence of polyethylene glycol. Ceram Int 34:1747–1751

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Materials and Metallurgical Engineering, School of Engineering, Ferdowsi University of Mashhad, P.O. Box 91775-1111, Mashhad, Iran

    Kh. Yousefi & J. Vahdati Khaki

  2. Department of Materials Science and Engineering, Engineering Faculty, Shiraz University, Shiraz, Iran

    S. Mojtaba Zebarjad

Authors
  1. Kh. Yousefi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. Mojtaba Zebarjad
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. Vahdati Khaki
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to S. Mojtaba Zebarjad.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yousefi, K., Zebarjad, S.M. & Vahdati Khaki, J. Comparison of polyethylene glycol effect on hydroxyapatite morphology produced into different methods: sol–gel and precipitation. J Sol-Gel Sci Technol 76, 592–598 (2015). https://doi.org/10.1007/s10971-015-3809-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10971-015-3809-y

Keywords

Search

Navigation