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Photoregulated uptake and release of drug by an organic–inorganic hybrid sol–gel material

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Abstract

A photo-responsive molecularly imprinted sol–gel organic-inorganic hybrid material prepared by covalent imprinting of the template-functional monomer complex formed between 4,4′-dihydroxylazobenzene and ibuprofen was developed to explore the photo-regulated uptake and release of drug by a silicate-based smart molecularly imprinted materials. After imprinting, the template molecules (ibuprofen) were removed via hydrolysis in acid, and accurate cavities were left, which could be used as the receptor recognition sites for ibuprofen. The new organic–inorganic hybrid material shows specific affinity to ibuprofen and reversible uptake and release of ibuprofen upon alternate irradiation at 365 and 440 nm, respectively. The favorable binding strength of the imprinted receptor sites in the molecularly imprinted polymer (MIP) for ibuprofen is found to be 2.28 × 103 M−1. Density of receptor sites in the MIP material was 4.0 µmol/g—MIP.

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Acknowledgments

The work described in this paper was supported by the Research Funds for the Doctoral Program of Higher Education of China (20090182120010), the National Natural Science Foundation of China (20872121), Natural Science Foundation Project of CQ CSTC (CSTC, 2009BB4001), the Fundamental Research Funds for the Central Universities (XDJK2009C011, XDJK2009C178), Southwest University Doctoral Fund (SWUB2008075), Postdoctoral Fund of Southwest University.

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Authors and Affiliations

  1. College of Chemistry and Chemical Engineering, Southwest University, 400715, Beibei, Chongqing, People’s Republic of China

    Qian Tang, Chengbin Gong & Xiangkai Fu

  2. Deapartment of Biology and Chemistry, The City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong

    Michael Hon-Wah Lam

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  1. Qian Tang
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  2. Chengbin Gong
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  3. Michael Hon-Wah Lam
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  4. Xiangkai Fu
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Correspondence to Chengbin Gong.

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Tang, Q., Gong, C., Lam, M.HW. et al. Photoregulated uptake and release of drug by an organic–inorganic hybrid sol–gel material. J Sol-Gel Sci Technol 59, 495–504 (2011). https://doi.org/10.1007/s10971-011-2518-4

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  • DOI: https://doi.org/10.1007/s10971-011-2518-4

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