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Sol–gel derived mesoporous bioactive glass fibers as tissue-engineering scaffolds

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Abstract

Mesoporous bioactive glass (MBG) fibers have been synthesized using the combination of a sol–gel process and a high velocity spray procedure by carefully controlling the sol composition, acidity and water content. A three-dimensional (3D) macro-structure with ∼50–100 μm interconnected macropores is formed in the spraying process. The MBG fibers possess well-ordered hexagonal mesostructure and excellent in vitro bioactivities. Sprague–Dawley (SD) rat osteoblasts have been cultured on MBG fibers. It is found that the MBG fibers have good cell biocompatibility and the 3D macro-structure is beneficial for cell attachment. It is anticipated that MBG fibers with controlled mesostructure and excellent in vitro bioactivity are good candidates for future tissue-engineering scaffolds.

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Acknowledgements

The authors thank the National Science Foundation of China (20573021, 30571877), Shanghai Science Committee (05DJ14005) and Shanghai Leading Academic Discipline Project (B113), the Ministry of Education of China (20060246010, FANEDD 200423) for financial supports.

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Authors and Affiliations

  1. Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai, 200433, P.R. China

    Jing Yi, Guangfeng Wei, Xiaohui Huang, Lingzhi Zhao & Chengzhong Yu

  2. Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai, 200433, P.R. China

    Quan Zhang

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  1. Jing Yi
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  2. Guangfeng Wei
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  3. Xiaohui Huang
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  4. Lingzhi Zhao
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  5. Quan Zhang
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  6. Chengzhong Yu
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Correspondence to Chengzhong Yu.

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Yi, J., Wei, G., Huang, X. et al. Sol–gel derived mesoporous bioactive glass fibers as tissue-engineering scaffolds. J Sol-Gel Sci Technol 45, 115–119 (2008). https://doi.org/10.1007/s10971-007-1668-x

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  • DOI: https://doi.org/10.1007/s10971-007-1668-x

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