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Synthesis and biodistribution of novel dipicolylamine 99mTc-(CO)3-labeled fatty acid derivatives for myocardial imaging

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Abstract

Six novel long chain fatty derivatives with dipicolylamine ligand were designed and synthesized and incorporated with fac-[99mTc(CO)3]+ as potential myocardial metabolic SPECT agents. They were prepared in a radiolabeling yield and demonstrated positively charged. The chemical stability of these compounds were good. Biodistribution studies were performed in normal mice, all compounds showed good initial heart uptake and retention, for 1b the heart uptake was 3.28 %ID/g at 1 min and could keep with 1.11 %ID/g at 60 min, it also showed a rapid blood clearance (blood1 min/blood60 min = 28).

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Acknowledgments

We gratefully acknowledged the financial support of Significant New Drugs Development (Grant No. 2014ZX09507007-001), Natural Science Foundation of China (No. 21371026) and Science and Technology Support Program (No. 2014BAA03B03).

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Authors and Affiliations

  1. Key Laboratory of Radiopharmaceuticals of Ministry of Education, College of Chemistry, Beijing Normal University, Beijing, 100875, China

    Qianqian Xue, Huan Wang, Jianping Liu, Dawei Wang & Huabei Zhang

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  1. Qianqian Xue
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  2. Huan Wang
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  5. Huabei Zhang
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Correspondence to Huabei Zhang.

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Xue, Q., Wang, H., Liu, J. et al. Synthesis and biodistribution of novel dipicolylamine 99mTc-(CO)3-labeled fatty acid derivatives for myocardial imaging. J Radioanal Nucl Chem 310, 1181–1194 (2016). https://doi.org/10.1007/s10967-016-4916-0

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