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Synthesis of a theranostic agent: radioiodinated PEGylated PLGA-indocyanine capsules and in vitro determination of their bioaffinity on ovarian, cervical and breast cancer cells

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Abstract

The aim of current study is to synthesize a theranostic (multi-functional) agent, which is targeted on ovary, cervical and breast cancer types with diagnosis and treatment potential and to determine its bioaffinity by using in vitro methods. In conclusion; the designed compound (IPPP), which has fluorescence capability (from Indocyanine), encapsulated structure (with PEGylated PLGA), included an anticancer drug (Paclitaxel) for targeting and radionuclidic tracer (131I) content for tracing, has bioaffinity and promise for diagnosis and therapy on ovarian, cervical and breast cancer cell lines.

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Acknowledgments

This work is supported by Ege University Research Fund (contract no 2014-TIP-085). The authors thank to Emine Derviş, Tansu Doğan, Ezgi Sulu, Onur Yıldız, Göksu Işık, Alper Kan and Büşra Karatay for the technical assistance during the in vitro experiments.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Faculty of Medicine, Ege University, 35100, Bornova, Izmir, Turkey

    Levent Akman, Ahmet Bilgi, Sevki Goksun Gokulu & Mustafa Cosan Terek

  2. Department of Nuclear Applications, Institute of Nuclear Sciences, Ege University, 35100, Bornova, Izmir, Turkey

    Fazilet Zumrut Biber Muftuler, Ayfer Yurt Kilcar & Emin Ilker Medine

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  1. Levent Akman
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  2. Fazilet Zumrut Biber Muftuler
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Correspondence to Fazilet Zumrut Biber Muftuler.

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Akman, L., Biber Muftuler, F.Z., Bilgi, A. et al. Synthesis of a theranostic agent: radioiodinated PEGylated PLGA-indocyanine capsules and in vitro determination of their bioaffinity on ovarian, cervical and breast cancer cells. J Radioanal Nucl Chem 308, 659–670 (2016). https://doi.org/10.1007/s10967-015-4472-z

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  • DOI: https://doi.org/10.1007/s10967-015-4472-z

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