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Synthesis and characterization of 68Ga labeled Fe3O4 nanoparticles for positron emission tomography (PET) and magnetic resonance imaging (MRI)

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Abstract

We designed a 68Ga labeled Fe3O4 nano-biocomposite for dual applications as diagnostic imaging agent in positron emission tomography (PET)/magnetic resonance imaging (MRI). The nano-biocomposites (68GaNHFCNP) were fabricated via surface modified iron oxide nanoparticles and NOTA as bi-functional chelating agent with 68Ga isotopes from 68Ge/68Ga generator. The structure and morphological properties of nano-biocomposite was characterized by XRD, TEM and IR analysis. 68GaNHFCNPs exhibits very low cytotoxicity and high cellular uptake upon SK-BR-3 and CT-26 cell lines. The advantages of high biocompatibility, magnetism and cell uptake make this composite promising as a potential probe of PET/MRI for effective detection of cancer.

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Acknowledgments

This research was supported by Nuclear R&D Program (2012M2A2A7035, 2010-0025899) and the Converging Research Center Program (2013K000339) and National Research Foundation of Korea (NRF) (20142M2A2A6043061) through the Ministry of Science, ICT and Future Planning.

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Authors and Affiliations

  1. Department of Chemistry, Dongguk University-Seoul, 30 Pildong-ro 1-Gil, Jung-gu, Seoul, 100-715, Republic of Korea

    Bo-Bae Cho, Soon Jae Jung, Jung Hoon Lee, C. Justin Raj & Kook-Hyun Yu

  2. Radiation Instrumentation Research Division, Korea Atomic Energy Research Institute, Jeongeup, 580-185, Republic of Korea

    Jeong Hoon Park, JunYoung Lee & Min Goo Hur

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  1. Bo-Bae Cho
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Correspondence to Kook-Hyun Yu.

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Cho, BB., Park, J.H., Jung, S.J. et al. Synthesis and characterization of 68Ga labeled Fe3O4 nanoparticles for positron emission tomography (PET) and magnetic resonance imaging (MRI). J Radioanal Nucl Chem 305, 169–178 (2015). https://doi.org/10.1007/s10967-015-4026-4

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  • DOI: https://doi.org/10.1007/s10967-015-4026-4

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