Abstract
Targeted alpha therapy is especially interesting for therapy of microscopic cancer tumors due to short path length and high linear energy transfer of the alpha particles. One of the most promising nuclides for targeted alpha therapy is 211At. To facilitate larger clinical studies using 211At, the current manual synthesis of radiolabeled antibodies would benefit from being transferred into an automated method. In this work, successful modifications of the manual synthesis have been performed in order to adapt it to automation. The automatic synthesis has also been tested using the modified synthesis method.
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The Inga Britt and Arne Lundbergs Research Foundation, The Swedish Cancer Society and the King Gustaf V Jubilee Clinic Research Foundation are acknowledged for the funding of this work.
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Aneheim, E., Jensen, H., Albertsson, P. et al. Astatine-211 labeling: a study towards automatic production of astatinated antibodies. J Radioanal Nucl Chem 303, 979–983 (2015). https://doi.org/10.1007/s10967-014-3561-8
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DOI: https://doi.org/10.1007/s10967-014-3561-8