Abstract
In the present study, an attempt has been made to quantify Oxygen Enhancement Ratio (OER) and variation of OER as a function of dose with experimental and theoretical formulations using Saccharomyces cerevisiae D7, X2180 and rad 52. The study confirms that, the variation of OER with dose depends upon type of cell and repair proficiency of cells. A theoretical model has been formulated to estimate OER values. With the help of this model, OER value for any dose can be calculated in the exponential region of the survival curve without actually extending the experiment in that dose region.
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Acknowledgments
The authors from Mangalore University are grateful to Board of Research in Nuclear Sciences, Department of Atomic Energy, Government of India, for the financial support. Authors are thankful to Dr. D.N. Sharma, Director, HSE&G, BARC, Mr.D.A.R.Babu, Head, RP&AD, BARC, India for technical discussions, support and help. Technical assistance during the experiments by Mr. U. B. Thorat, Mr. S. Jagtap and Mr. P. J. Tondlekar are thankfully acknowledged.
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Nairy, R.K., Bhat, N.N., Anjaria, K.B. et al. Study of gamma radiation induced damages and variation of oxygen enhancement ratio with radiation dose using Saccharomyces cerevisiae . J Radioanal Nucl Chem 302, 1027–1033 (2014). https://doi.org/10.1007/s10967-014-3408-3
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DOI: https://doi.org/10.1007/s10967-014-3408-3