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Production, nano-purification, radiolabeling and biodistribution study of [140Nd] 5,10,15,20-tetraphenylporphyrin complex as a possible imaging agent

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Abstract

[140Nd] labeled 5,10,15,20-tetraphenylporphyrin ([140Nd]-TPP) as a tumor–avid complex with a β-emitting radionuclide for evaluating its potential for target tumor therapy is reported. This complex was prepared using freshly prepared [140Nd] NdCl3 (purified by amino functionalized MCM-41 nano resin and commercial cation exchanger resins) and 5,10,15,20-tetraphenylporphyrin (H2TPP).Stability of the complex was investigated in final formulation and human serum for 24 h and the partition coefficient was calculated. The biodistribution of the labeled compound in vital organs of Swiss mice bearing fibro sarcoma tumor was studied using scarification studies and positron emission tomography imaging up to 4 h.

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References

  1. Sanderson DR, Fontana RS, Lipson RL, Baldes EJ (1972) Hematoporphyrin as a diagnostic tool; a preliminary report of new techniques. Cancer 30:1368–1372

    Article  CAS  Google Scholar 

  2. Ethan DS, David D (1998) Tetrahedron 54:4151–4202

    Article  Google Scholar 

  3. Fawwaz R, Bohdiewicz P, Lavallee D, Wang T, Oluwole S, Newhouse J, Alderson P (1990) Use of metallo porphyrins in diagnostic imaging. Int J Radiat Appl Instrum B 17:65–72

    Article  CAS  Google Scholar 

  4. Firestone RB, Shirley VS, Baglin CM, Zipkin J (1996) In: Table of isotopes, 8th edn. Wiley, New York, p. 1447

  5. Ro¨sch F, Brockmann J, Lebedev NA, Qaim SM (2000) Production and radiochemical separation of the auger electron emitter 140Nd. Acta Oncol 39:727

    Article  Google Scholar 

  6. Thomas SR, Khuntia D (2007) Motexafin gadolinium injection for the treatment of brain metastases in patients with non-small cell lung cancer. Int J Nanomed 2:79–87

    Article  CAS  Google Scholar 

  7. Kahl SB, Koo MS (1992) Synthesis and properties of tetrakiscarborane-carboxylate esters of 2,4-bis (-di hydroxyethyl) deuteron porphyrin IX. In: Allen BJ, Moore DE, Harrington BV (eds) Progress in neutron capture therapy for cancer. Plenum Press, New York, pp 223–226

    Chapter  Google Scholar 

  8. Sasaki K, Yumita N, Nishigaki R, Sakata I, Nakajima S, Umemura S-I (2001) Pharmacokinetic study of a gallium-porphyrin photo- and sono-sensitizer, ATX-70, in tumor-bearing mice. Jpn J Cancer Res 92:989–995

    Article  CAS  Google Scholar 

  9. Fawwaz RA, Frye F, Loughman WD, Hemphill W (1974) Survival of skin homografts in dogs injected with 109Pd-protoporphyrin. J Nucl Med 15:997–1002

    CAS  Google Scholar 

  10. Fawwaz RA, Hemphill W, Winchell HS (1971) Potential use of 109Pd-porphyrin complexes for selective lymphatic ablation. J Nucl Med 12:231–236

    CAS  Google Scholar 

  11. Chakraborty S, Das T, Banerjee S, Sarma HD, Venkatesh M (2007) Preparation and preliminary biological evaluation of a novel 109Pd labeled porphyrin derivative for possible use in targeted tumor therapy. Q J Nucl Med Mol Imaging 15:16–23

    Google Scholar 

  12. Sarma HD, Das T, Banerjee S, Venkatesh M, Vidyasagar PB, Mishra KP (2010) Biological evaluation of a novel 188Re-labeled porphyrin in mice tumor model. Cancer Biother Radiopharm 25:47–54

    Article  CAS  Google Scholar 

  13. Murugesan S, Shettyc SJ, Srivastava TS, Noronha OPD, Samuel AM (2001) A technetium-99m-labelled cyclam acid porphyrin (CAP) for tumour imaging. Appl Radiat Isot 55:641–646

    Article  CAS  Google Scholar 

  14. Wang A-Y, Lin J-L, Lin W-C (2010) Studies on the porphine labeled with 99mTc–pertechnetate. J Radioanal Nucl Chem 284:121–128

    Google Scholar 

  15. Fazaeli Y, Jalilian AR, Amini MM et al (2012) Radiosynthesis and biological evaluation of [111In]-5,10,15,20-tetrakis (pentafluorophenyl) porphyrin complex as a possible imaging agent. Int J Nucl Energy Sci Eng 2:28

    Article  Google Scholar 

  16. Fazaeli Y, Jalilian AR, Amini MM et al (2011) Preparation and preliminary evaluation of [67Ga]-tetra phenyl porphyrin complexes as possible imaging agents. J Radioanal Nucl Chem 288:17–24

    Article  CAS  Google Scholar 

  17. Fazaeli Y, Jalilian AR, Amini MM et al (2012) Development of a 68Ga-fluorinated porphyrin complex as a possible PET imaging agent. Nucl Med Mol Imaging 46:20–26

    Article  CAS  Google Scholar 

  18. Falk JE (1975) Porohyrins and metallo porphyrins. Elsevier Science Publishing, New York

    Google Scholar 

  19. Yoshitake H, Yokoi T, Tatsumi T (2002) Chem Mater 14:4603

    Article  CAS  Google Scholar 

  20. Peng QR, Yang Y, Yuan YZ (2004) J Mol Catal A: Chem 219:175

    Article  CAS  Google Scholar 

  21. Steyn GF, Vermeulen C, Nortier FM, Szelecsényi F, Kovács Z, Qaim SM (2006) Production of no-carrier-added 139Pr via precursor decay in the proton bombardment of natPr. Nucl Instrum Methods Phys Res B 252:149–159

    Article  CAS  Google Scholar 

  22. Adler AD, Longo FR, Finarelli JD, Goldmacher J, Assour J, Korsakoff L (1967) A simplified synthesis for meso-tetraphenylporphine. J Org Chem 32:476

    Article  CAS  Google Scholar 

  23. Jalilian AR, Rowshanfarzad P, Sabet M, Novinrooz A, Raisali G (2005) Preparation of [66Ga]bleomycin complex as a possible PET radiopharmaceutical. J Radioanal Nucl Chem 264:617

    Article  CAS  Google Scholar 

  24. Beck JS, Vartuli JC, Roth WJ, Leonowicz ME, Kresge CT, Schmitt KD, Chu CT-W, Olson DH, Sheppard EW, Mc. Cullen SB, Higgins JB, Schlenker JL (1992) A new family of mesoporous molecular sieves prepared with liquid crystal templates. J Am Chem Soc 114:10834

    Article  CAS  Google Scholar 

  25. Lam K, Chen X, McKay G, Yeung K (2008) Anion effect on Cu2+ adsorption on NH2-MCM-41. Ind Eng Chem Res 47:9376

    Article  CAS  Google Scholar 

  26. Leofarrti G, Padovan M, Tozzola G, Venturelli B (1998) Surface area and pore texture of catalysts. Catal Today 41:207

    Article  Google Scholar 

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Acknowledgments

Authors wish to thank Ms. Fateme bolori novin & Ms. Sedighe moradkhani for conducting animal studies.

Conflict of interest

The authors report no conflicts of interest in this work.

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Authors and Affiliations

  1. Nuclear Medicine Research Group, Agricultural, Medical and Industrial Research School (AMIRS), P.O. Box 31485-498, Karaj, Iran

    Mohammadreza Aboudzadeh & Yousef Fazaeli

  2. Department of Nuclear Engineering and Physics, Amir-kabir, University of Technology, P.O. Box 4155-4494, Tehran, Iran

    Helma Khodaverdi & Hossein Afarideh

Authors
  1. Mohammadreza Aboudzadeh
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  2. Yousef Fazaeli
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  3. Helma Khodaverdi
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  4. Hossein Afarideh
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Correspondence to Yousef Fazaeli.

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Aboudzadeh, M., Fazaeli, Y., Khodaverdi, H. et al. Production, nano-purification, radiolabeling and biodistribution study of [140Nd] 5,10,15,20-tetraphenylporphyrin complex as a possible imaging agent. J Radioanal Nucl Chem 295, 105–113 (2013). https://doi.org/10.1007/s10967-012-1826-7

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  • DOI: https://doi.org/10.1007/s10967-012-1826-7

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