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Production of cationic 198Au3+ and nonionic 198Au0 for radionuclide therapy applications via the natAu(n,γ)198Au reaction

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Abstract

198Au (βmax = 0.96 MeV (98.6 %), γmax = 0.412 MeV (95.5 %) and T 1/2  = 2.7 days) is a radionuclide with very appealing characteristics. 198Au has been widely used to treat the uterus, bladder, cervix, prostate, melanoma, breast, skin and other cancers. In the present study, cationic 198Au+3 and nonionic 198Au0 are prepared following thermal neutron irradiation of commercially available natural gold compounds in Tehran Research Reactor via the natAu(n,γ)198Au reaction. The prospects in the production of pure 198Au0 and 198Au+3 for radionuclide therapy are discussed and effect of reduction on the activity of radioactive gold is evaluated. Au0 particles were synthesized via NaBH4 reduction of aqueous solutions of hydrogen tetrachloroaurate trihydrate. Then two quartz tubes were charged with cationic 198Au3+ and nonionic 198Au0. After irradiation by thermal neutrons, the samples were analyzed for a period of 1 month by liquid scintillation counter and high purity germanium detector. As a result, natAu3+ reduction process had no significant effect on the activity of the 198Au sample. In conclusions, natural gold thermal neutron activation cross section is reasonably high for medical application.

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Authors and Affiliations

  1. Agricultural, Medical and Industrial Research School, Nuclear Science and Technology Research Institute, P.O. Box 31485/498, Karaj, Tehran, Iran

    Mahdi Sadeghi

  2. Department of Medical Radiation Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran

    Hamidreza Jabal-Ameli

  3. Jaber Ibne Hayan Research Laboratories, Nuclear Science and Technology Research Institute, P.O. Box 11365-8486, Tehran, Iran

    Seyed J. Ahmadi & Sodeh S. Sadjadi

  4. Young Researchers Club, Science and Research Branch, Islamic Azad University, Tehran, Iran

    Mohamadreza K. Bakht

Authors
  1. Mahdi Sadeghi
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  2. Hamidreza Jabal-Ameli
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  3. Seyed J. Ahmadi
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  4. Sodeh S. Sadjadi
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  5. Mohamadreza K. Bakht
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Correspondence to Mahdi Sadeghi.

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Sadeghi, M., Jabal-Ameli, H., Ahmadi, S.J. et al. Production of cationic 198Au3+ and nonionic 198Au0 for radionuclide therapy applications via the natAu(n,γ)198Au reaction. J Radioanal Nucl Chem 293, 45–49 (2012). https://doi.org/10.1007/s10967-012-1772-4

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  • DOI: https://doi.org/10.1007/s10967-012-1772-4

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