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The analysis of radiolysis impurities in 18F-FDG and methods of repurification

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Abstract

To investigate the radio impurity in the radiolysis of 18F-FDG at high radiodose and radioconcentrated solutions and develop methods of repurification. The radiolysis of 18F-FDG was analyzed by TLC. The radio-impurity was confirmed by biodistribution and small animal PET/CT studies. 18F-FDG was unstable at high radioconcentrition over 37 GBq/mL or under basic condition. TLC, biodistribution and PET/CT all indicated that the main autoradiolysis byproduct was free fluoride ion. The radiolyzed 18F-FDG was repurified by solid-phase extraction (SPE) column. The repurified 18F-FDG had a radiochemical purity (RCP) of over 99% and significantly lower bone uptake than that was before repurification (P = 0.0003). There was a positive correlation between the recovery yield and the purity of 18F-FDG (R 2 = 0.66).

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Authors and Affiliations

  1. Department of Nuclear Medicine, The PLA General Hospital, 100853, Beijing, China

    Jinming Zhang, Yungang Li, Jian Liu, Xiaojun Zhang & Jiahe Tian

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  1. Jinming Zhang
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  2. Yungang Li
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  3. Jian Liu
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  4. Xiaojun Zhang
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  5. Jiahe Tian
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Correspondence to Jiahe Tian.

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Zhang, J., Li, Y., Liu, J. et al. The analysis of radiolysis impurities in 18F-FDG and methods of repurification. J Radioanal Nucl Chem 283, 565–569 (2010). https://doi.org/10.1007/s10967-009-0408-9

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  • DOI: https://doi.org/10.1007/s10967-009-0408-9

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