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Synthesis, labeling and biodistribution of 99mTc-3-amino-2-quinoxalin-carbonitrile 1,4-dioxide in tumor bearing mice

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Abstract

3-Amino-2-quinoxalincarbonitrile 1,4-dioxide (AQCD) is a quinoxaline derivative, which was synthesized by condensation method. AQCD was labeled with 99mTc with labeling yield above 90% investigated by paper chromatography. 99mTc-AQCD was prepared using stannous chloride as reducing agent at pH 7 and 10 min reaction time. 99mTc-AQCD should be freshly prepared, otherwise the yield significantly decreased after 15 min post labeling. Stability study of 99mTc-AQCD reflected the short time stability of Biodistribution study of 99 mTc-AQCD in tumor bearing mice reflected that its uptake in tumor sites in both ascites and solid tumor sites. This uptake of 99mTc-AQCD in tumor sites was sufficient to radioimage the inoculated sites.

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Authors and Affiliations

  1. Labelled Compounds Department, Radioisotopes Production and Radioactive Sources Division, Hot Laboratories Center, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt

    I. T. Ibrahim

  2. Faculty of Science (Damietta), Mansoura University, Mansoura, Egypt

    M. A. Wally

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  1. I. T. Ibrahim
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  2. M. A. Wally
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Correspondence to I. T. Ibrahim.

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Ibrahim, I.T., Wally, M.A. Synthesis, labeling and biodistribution of 99mTc-3-amino-2-quinoxalin-carbonitrile 1,4-dioxide in tumor bearing mice. J Radioanal Nucl Chem 285, 169–175 (2010). https://doi.org/10.1007/s10967-009-0039-1

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  • DOI: https://doi.org/10.1007/s10967-009-0039-1

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