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Synthesis and biodistribution of 99mTc-peptides conjugated adenine as tumor imaging agents

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Abstract

Two peptide ligands conjugated adenine, [9-N-(tritylmercapto acetyl diglycyl aminoethyl) adenine, Tr-MAG2-Ade] and [9-N-(tritylmercapto acetyl triglycyl aminoethyl) adenine, Tr-MAG3-Ade], are synthesized and labeled with 99mTc by directly labeling method. The stability of 99mTc-MAG2-adenine and 99mTc-MAG3-adenine in vitro is measured. The uptake radios of tumor to muscle at 3h post-injection are 5.70 and 4.92, respectively. The biodistribution and scintigraphic imaging studies show that the two complexes have high localization in tumor and high contrasted tumor images can be obtained, which suggest their potential utility as tumor imaging agents. But the high radioactivity of abdomen could prevent the tumor imaging in this area.

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Authors and Affiliations

  1. Department of Chemistry, Beijing Normal University, Beijing, 100875, P.R. China

    Y. L. Zhao, C. M. Qi, S. J. Feng & G. R. You

  2. Department of Nuclear Medicine, Peking University First Hospital, Beijing, 100034, P.R. China

    C. L. Zhang, Z. L. Fu, F. G. Guo & R. F. Wang

Authors
  1. Y. L. Zhao
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  2. C. L. Zhang
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  3. C. M. Qi
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  4. S. J. Feng
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  5. G. R. You
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  6. Z. L. Fu
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  7. F. G. Guo
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  8. R. F. Wang
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Zhao, Y.L., Zhang, C.L., Qi, C.M. et al. Synthesis and biodistribution of 99mTc-peptides conjugated adenine as tumor imaging agents. J Radioanal Nucl Chem 273, 9–13 (2007). https://doi.org/10.1007/s10967-007-0702-3

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  • DOI: https://doi.org/10.1007/s10967-007-0702-3

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