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Identification of target organs of copper nanoparticles with ICP-MS technique

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Abstract

Nanosized copper particles are widely used in fields of lubricants, polymers/plastic, metallic coating and ink. Recently, we found that copper particles in different sizes can lead to different toxicological effects. To clarify the target organs of copper particles of different sizes, the inductively coupled plasma mass spectroscopy (ICP-MS) was employed to evaluate the distribution of copper in different organs of mice after a single dose oral exposure. The results suggest that the main target organs for copper nanoparticles are kidney, liver and blood. Liver is the main damaged organ.

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Authors and Affiliations

  1. Laboratory for Bio-Environmental Health Sciences of Nanoscale Materials, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, P.R. China

    Zhen Chen, Huan Meng, Hui Yuan, Gengmei Xing, Chunying Chen, Feng Zhao, Yun Wang, Chengcheng Zhang & Yuliang Zhao

  2. The Graduate University of Chinese Academy of Sciences, Beijing, 100049, P.R. China

    Zhen Chen, Huan Meng, Yun Wang, Chengcheng Zhang & Yuliang Zhao

  3. National Center for Nanoscience and Nanotechnology, China, Beijing, 100081, P.R. China

    Chunying Chen & Yuliang Zhao

Authors
  1. Zhen Chen
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  2. Huan Meng
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  3. Hui Yuan
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  4. Gengmei Xing
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  5. Chunying Chen
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  6. Feng Zhao
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  7. Yun Wang
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  8. Chengcheng Zhang
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  9. Yuliang Zhao
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Chen, Z., Meng, H., Yuan, H. et al. Identification of target organs of copper nanoparticles with ICP-MS technique. J Radioanal Nucl Chem 272, 599–603 (2007). https://doi.org/10.1007/s10967-007-0631-1

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  • DOI: https://doi.org/10.1007/s10967-007-0631-1

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