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A 228Ra-212Pb tandem generator for potential application in biomedical studies

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Abstract

A new tandem generator system (cation-exchange generator column coupled to anion-exchange), based on the 228Ra as starting radionuclide, for 212Pb/212Bi production in the solutions suitable to direct application in biomedical investigations has been developed. Optimum conditions have been found for retention of Ra, Th and Ac parent radionuclides on the cation-exchange column and repeated elution of Pb with subsequent concentration on anion-exchange column using HBr and mixed HBr/CH3OH solutions. It was shown that Pb/Bi could be eluted from anion — exchange column with a small volume of EDTA, DTPA, NaCl solutions or heated H2O. The advantages of the tandem generator system for production of short-lived Pb/Bi radionuclides and their application for biomedical studies are discussed.

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Authors and Affiliations

  1. V. I. Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences, 117975, Moscow, Kosigin St., 19, Russia

    L. I. Guseva

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  1. L. I. Guseva
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Guseva, L.I. A 228Ra-212Pb tandem generator for potential application in biomedical studies. J Radioanal Nucl Chem 272, 153–159 (2007). https://doi.org/10.1007/s10967-006-6805-4

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  • DOI: https://doi.org/10.1007/s10967-006-6805-4

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