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Preparation of carboxymethylchitosan based rapid self-healing injectable hydrogels

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Abstract

Carboxymethylchitosan (CMCS) was prepared in a strong alkaline mixture system of isopropyl alcohol and water, and the substitution degrees of carboxymethylation on -OH and –NH2 groups of chitosan were 58% and 5%, respectively. A series of hydrogels were obtained by mixing 1 wt%-5 wt% aqueous solution of CMCS with aldehyde-4-arm polyethylene glycol (4r-PEG-CHO) and ZnCl2 at room temperature at pH=6. The presence of a chemical and physical cross linker in the same time, 4r-PEG-CHO and ZnCl2, enhanced the mechanical properties of hydrogels and the storage modulus of the gels reached up to 1562 Pa. This may be due to a synergistic effect of imine bonds, metal coordination and hydrogen bonding. The hydrogels exhibited good injectability, pH sensitivity and rapid self-healing ability. Macroscopic observation and dynamic rheological results showed that the hydrogels could self-heal within 1 min after being damaged. This novel rapid self-healing injectable hydrogel has potential applications in the field of biomedicine.

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Acknowledgement

We acknowledge Kunshan Jingkun Oilfield Chemistry Company for providing financial support.

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Author notes

  1. Bo Xiao

    Present address: School of Chemistry, Key Laboratory of Green Chemistry and Technology Ministry of Education, Sichuan University, Chengdu, 610064, China

Authors and Affiliations

  1. School of Chemistry, Key Laboratory of Green Chemistry and Technology Ministry of Education, Sichuan University, Chengdu, 610064, China

    Han Shi, Aoqi Li & Bo Jiang

  2. Kunshan Jingkun Oilfield Chemistry Company, Kunshan, 215337, China

    Chuanzhi Hu, Xuewei Lin & Mingyu Deng

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  1. Han Shi
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Shi, H., Hu, C., Li, A. et al. Preparation of carboxymethylchitosan based rapid self-healing injectable hydrogels. J Polym Res 30, 342 (2023). https://doi.org/10.1007/s10965-023-03705-7

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