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Two Cu(II)-bearing coordination polymers: magnetic properties and application values on vaginitis by balancing the microbial ecology in the vagina

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Abstract

In the presence/absence of N-donor ancillary ligands, through utilizing two well-designed chiral 4,4′-oxybisbenzoyl alanine/proline derivatives, two new Cu(II)-bearing coordination polymers whose chemical formulae are [Cu(ODBALa)H2O]·H2O (1, H2ODBALa = 4,4′-oxybisbenzoyl-bis(L-alanine)) and [Cu(ODBPRo)(dpy)]·7H2O (2, H2ODBPRo = 4,4′-oxybisbenzoyl-bis(L-proline), dpy = (E)-1,2-di(pyridin-4-yl)diazene) have been fabricated via a solvothermal preparation method. The magnetic researches demonstrate that compounds 1 and 2 have antiferromagnetic catena among the neighboring metal ions. Their application values on the mixed vaginitis were assessed and the mechanism involved was also discussed. Firstly, after prescribed treatment, an ELISA (enzyme linked immunosorbent assay) detection was used to evaluated the inflammatory levels in the body. Apart from this, the real-time RT-PCR (reverse transcription-polymerase chain reaction) was performed and the Lactobacillus abundance was measured. Compound 1 was better than compound 2 on the vaginitis treatment.

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Authors and Affiliations

  1. Department of Obstetrics, Jinan Third People’s Hospital, Jinan, Shandong, China

    Hong-Qin Xie, Yan-Bing Li, Qing-Chao Tian & Qing-Li Fan

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  1. Hong-Qin Xie
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  2. Yan-Bing Li
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Xie, HQ., Li, YB., Tian, QC. et al. Two Cu(II)-bearing coordination polymers: magnetic properties and application values on vaginitis by balancing the microbial ecology in the vagina. J Polym Res 28, 208 (2021). https://doi.org/10.1007/s10965-021-02556-4

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