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Radiation crosslinking polymerization of poly (vinyl alcohol) and poly (ethylene glycol) with controlled drug release

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Abstract

The aim of this work was to develop novel polyvinyl alcohol (PVA) and polyethylene glycol (PEG) blends hydrogels via solution casting technique followed by γ-irradiation technique to crosslink and form a hydrogel material that contains a certain amount of water when the solution polymer was exposed to γ-radiation at a small dose rate at ambient temperature. The formation of the PVE: PEG cross-linked structure was confirmed by Fourier Transform Infrared Spectroscopy (FTIR) measurement. The degree of swelling increased with increases in PVA content in the PVA-PEG mixed gel. The drug released from the gel material was examined using drug model sodium sulfate. The drug release behavior from the hydrogel networks was influence by the PVA-PEG ratio in the hydrogel preparation. The released amount was influenced dramatically by the ratio of PVA in the initial feed. The kinetic of the drug released from the hydrogels in general was a non-Fickian diffusion type (anomalous) mechanisms, whereas the process is moderately affected by the viscoelastic relaxation of the chains through water penetration. The thermal stability behavior of the hydrogel was demonstrated by thermo-gravimetric analysis (TGA), the tensile strength and compressive strength were found to be increased with increasing PEG content under induced γ-radiation. Furthermore, biodegradability of the PVA: PEG polymer blends were estimated in phosphate buffer solutions (PBS) under different pH values and enzymatic solution at pH 7.4 through weight loss monitoring. The results indicated that the biodegradation was increased as a function of PEG content decreased. The gamma ray crosslinking of the PVA: PEG blend hydrogel can be a good candidate for applications in a drug career.

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References

  1. Rosiak JM, Yoshii F (1999) Hydrogels and their medical applications. Nucl. Inst. Methods Phys. Res. B 151:56–64

    Article  CAS  Google Scholar 

  2. Zhao L, Mitomo H, Zhai M, Yoshii F, Nagasawa N, Kume T (2003) Radiation synthesis and characteristic of the hydrogels based on carboxymethylated chitin derivatives. Carbohydr. Polym. 51:169–175

    Article  CAS  Google Scholar 

  3. Cascone MG, Sim B, Downes S (1995) Blends of synthetic and natural polymers as drug delivery systems for growth hormone. Biomaterials 16:569–574

    Article  CAS  Google Scholar 

  4. Mellott MB, Searcy K, Pishko MV (2001) Release of protein from highly cross-linked hydrogels of poly(ethylene glycol) diacrylate fabricated by UV polymerization. Biomaterials 22:929–941

    Article  CAS  Google Scholar 

  5. Sagle AC, Ju H, Freeman BD, Sharma MM (2009) PEG-based hydrogel membrane coatings. Polymer 50:756–766

    Article  CAS  Google Scholar 

  6. Hassan CM, Peppas NA (2000) Structure and applications of poly(vinyl alcohol) hydrogels produced by conventional crosslinking or by freezing/thawing methods. Adv. Polym. Sci. 153:37–65

    Article  CAS  Google Scholar 

  7. Mansur HS, Orefice RL, Mansur AAP (2004) Characterization of poly(vinyl alcohol)/poly(ethylene glycol)hydrogels and PVA-derived hybrids by small-angle X-ray scattering and FTIR spectroscopy. Polymer 45:7193–7202

    Article  CAS  Google Scholar 

  8. Wu M, Bao B, Yoshii F, Makuuchi K (2001) Irradiation of crosslinked, poly(vinyl alcohol) blended hydrogel for wound dressing. J. Radioanal. Nucl. Chem. 250:391–395

    Article  CAS  Google Scholar 

  9. Park KR, Nho YC (2003) Synthesis of PVA/PVP hydrogels having two-layer by radiation and their physical properties. Radiat. Phys. Chem. 67:361–365

    Article  CAS  Google Scholar 

  10. Abdel Moneam YA, Sakr HAA, Ali HE, Khalil SA, El-Naggar AWM (2014) Characterization and antimicrobial properties of gamma synthesized plasticized starch/poly(vinyl alcohol)/ZnO composites as protective coating for papers. International Journal of Chem Tech Research 6:2583–2597

    CAS  Google Scholar 

  11. Zakuraeva OA, Nesterov SV, Shmakova NA, Semenova GK, Sozontova EO, Feldman VI (2007) Radiation-chemical synthesis of poly(vinyl alcohol) hydrogel dicyclohexano-18-crown-6. Nucl. Inst. Methods Phys. Res. B 265:356–361

    Article  Google Scholar 

  12. Yang X, Yang K, Wu S, Chen X, Yu F, Li J, Ma M, Zhu Z (2010) Cytotoxicity and wound healing properties of PVA/ws-chitosan/glycerol hydrogels made by irradiation followed by freeze–thawing. Radiat. Phys. Chem. 79:606–611

    Article  CAS  Google Scholar 

  13. Gwon HJ, Lim YM, Nho YC, Baik SH (2010) Humectants effect on aqueous fluids absorption of γ-irradiated PVA hydrogel followed by freeze thawing. Radiat. Phys. Chem. 79:650–653

    Article  CAS  Google Scholar 

  14. Dutta J (2012) Synthesis and characterization of γ-irradiated PVA/PEG/CaCl2 hydrogel for wound dressing. Am. J. Chem. 2:6–11

    Article  Google Scholar 

  15. Nouh SA, Nagla AG, Othman MH, Eman SA, Lotfi ZI (2012) Thermal, structural, and optical properties of γ-irradiated poly(vinyl alcohol)/poly(ethylene glycol) thin film. J. Appl. Polym. Sci. 124:654–660

    Article  CAS  Google Scholar 

  16. Park J-S, Kim H, Choi J-B, Gwona H-J, Shin Y-M, Lim Y-M, Khil MS, Nho Y-C (2012) Effects of annealing and the addition of PEG on the PVA based hydrogel by gamma ray. Radiat. Phys. Chem. 81:857–860

    Article  CAS  Google Scholar 

  17. Machado LDB, Bavaresco VP, Pino ES, Zavaglia CAC, Reis MC (2004) TA of pval of hydrogen cross-linked by chemical and eb irradiation process used as artificial articular cartilage. J. Therm. Anal. Calorim. 75:445–451

    Article  CAS  Google Scholar 

  18. Nugroho P, Mitomo H (2008) Study of biodegradation and improvement of heat stability of poly(lactic acid) by irradiation at high temperature. Malaysian Polymer Journal 3:27–37

    Google Scholar 

  19. Gulsen D, Chauhan A (2006) Effect of water content on transparency, swelling, lidocaine diffusion in p-HEMA gels. J. Membr. Sci. 269:35–48

    Article  CAS  Google Scholar 

  20. Kaity S, Isaac J, Ghosh J (2013) Interpreting polymer network of locust bean gum-poly (vinyl alcohol) for controlled release drug delivery. Carbohydr. Polym. 94:456–467

    Article  CAS  Google Scholar 

  21. Satish CS, Satish KP, Shivakumar HG (2006) Hydrogels as controlled drug delivery systems: synthesis, crosslinking, water and drug transport. Indian Journal of Pharmaceutical Sciences 68:133–140

    Article  CAS  Google Scholar 

  22. Singh B, Pal L (2011) Radiation crosslinking polymerization of sterculia polysaccharide-PVA-PVP for making hydrogel wound dressings. Int. J. Biol. Macromol. 48:501–510

    Article  CAS  Google Scholar 

  23. Wang, M., Xu, L., Hui, H., Zhai, M., Peng., J., Nho, J., Li, J., and Wei, G (2007) Radiation synthesis of PVP/CMC hydrogels as wound dressing. Nucl. Inst. Methods Phys. Res. B 265: 385–389.

  24. Singh B (2007) Psyllium as therapeutic and drug delivery agent. Int. J. Pharm. 334:1–14

    Article  CAS  Google Scholar 

  25. Zalipsky S (1995) Chemistry of polyethylene glycol conjugates with biologically active molecules. Adv. Drug Deliv. Rev. 16:157–182

    Article  CAS  Google Scholar 

  26. González-Rodrígues ML, Maestrelli F, Mura P, Rabasco AM (2003) In vitro release of sodium diclofenac from a central core matrix tablet aimed for colonic drug delivery. Eur. J. Pharm. Sci. 20:125–131

    Article  Google Scholar 

  27. Rao KVR, Devi KP, Buri P (1990) Influence of molecular size and water solubility of the solute on its release from swelling and erosion controlled polymer matrices. J. Control. Release 12:133–141

    Article  CAS  Google Scholar 

  28. Bourke SL, Al-Khalili M, Briggs T, Michniak BB, Kohn J, Poole-Warren LA (2003) A photo-crosslinked poly(vinyl alcohol) hydrogel growth factor release vehicle for wound healing applications. AAPS Pharm Sci 5:101–111

    Article  Google Scholar 

  29. Lugao AB, Rogero SO, Malmonge SM (2002) Rheological behaviour of irradiated wound dressing poly(vinyl pyrrolidone) hydrogels. Radiat. Phys. Chem. 63:543–546

    Article  CAS  Google Scholar 

  30. Yusong P, Dangsheng X, Xiaolin C (2007) Mechanical properties of nanohydroxyapatite reinforced poly(vinyl alcohol) gel composites as biomaterial. J. Mater. Sci. 42:5129–5134

    Article  Google Scholar 

  31. Jin L, Bai RB (2002) Mechanisms of lead adsorption on chitosan/PVA hydrogel beads. Langmuir 18:9765–9770

    Article  CAS  Google Scholar 

  32. Minhas MU, Ahmad M, Ali L, Sohail M (2013) Synthesis of chemically cross-linked polyvinyl alcohol-co-poly (methacrylic acid) hydrogels by copolymerization; a potential graft-polymeric carrier for oral delivery of 5-flourouracil. J. Pharm. Sci. 21:44

    CAS  Google Scholar 

  33. Leitão AF, Silva JP, Dourado F, Gama M (2013) Production and characterization of a new bacterial cellulose/poly(vinyl alcohol) nanocomposite. Materials 6:1956–1966

    Article  Google Scholar 

  34. Bodugoz-Senturk H, Macias CE, Kung JH, Muratoglu OK (2009) Poly(vinyl alcohol)-acrylamide hydrogels as load-bearing cartilage substitute. Biomaterials 30:589–596

    Article  CAS  Google Scholar 

  35. Huang SJ (1985) Biodegradable polymers, in encyclopedia of polymer science and engineering, vol 2. Wiley, New York, p. 220

    Google Scholar 

  36. Ding M, Zhang M, Yang J, Qui JH (2012) Study on the enzymatic degradation of PBS and its alcohol acid modified copolymers. Biodegradation Epub 23:127–132

    Article  CAS  Google Scholar 

  37. Chan Woo Lee, Kimura. Jin-Do Chung (2008) Mechanism of enzymatic degradation of poly (butylone succinate). Macromol. Res. 16: 651–658.

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Acknowledgments

The authors acknowledge the financial support of the Libyan Authority for Research, Science & Technology-Tripoli, and the authors are also indebted to Nanocomposites Biomaterials Laboratory in the Faculty of Engineering - Architectural Science at Ryerson University in Toronto, Canada.

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Authors and Affiliations

  1. Department of Chemical Engineering, Ryerson University, Toronto, ON, M5B 2K3, Canada

    Mustafa Abu Ghalia & Yaser Dahman

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  1. Mustafa Abu Ghalia
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  2. Yaser Dahman
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Correspondence to Yaser Dahman.

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Abu Ghalia, M., Dahman, Y. Radiation crosslinking polymerization of poly (vinyl alcohol) and poly (ethylene glycol) with controlled drug release. J Polym Res 22, 218 (2015). https://doi.org/10.1007/s10965-015-0861-9

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