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Electrospun polycaprolactone/ZnO nanocomposite membranes as biomaterials with antibacterial and cell adhesion properties

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Abstract

In the present study we have investigated the effect of zinc oxide (ZnO) nanoparticles on the fiber diameter, fiber morphology, antibacterial activity, and enhanced cell proliferation of the electrospun polycaprolactone (PCL) non-woven membrane. The effect of the ZnO nanoparticle concentration on the fiber diameter and fiber morphology was investigated using a scanning electron microscope (SEM). Fourier transform infrared spectroscopy (FT-IR) analysis was carried out to determine the nature of the interaction between the PCL and the ZnO nanoparticles. We also investigated the mechanical stability and antibacterial activity of the fabricated material. Interestingly, the membranes with ZnO nanoparticles showed enhanced mechanical stability, antibacterial properties, fibroblast proliferation, and improved metabolic activity of the cells. Further, this is the first report regarding the ability of a biomaterial containing ZnO nanoparticles to enhance cell proliferation.

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Acknowledgments

The authors acknowledge the Department of Science and Technology (DST), Government of India, New Delhi, for the financial support through the Nanomission and PURSE programs. Funding from UGC SAP and DST-FIST are also gratefully acknowledged.

Conflict of Interest

The authors declare that they have no conflicts of interest.

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Authors and Affiliations

  1. International and Inter University Centre for Nanoscience and Nanotechnology, Mahatma Gandhi University, Kottayam, 686 560, Kerala, India

    Robin Augustine, Nandakumar Kalarikkal & Sabu Thomas

  2. School of Pure and Applied Physics, Mahatma Gandhi University, Kottayam, 686 560, Kerala, India

    Nandakumar Kalarikkal

  3. School of Chemical Sciences, Mahatma Gandhi University, Kottayam, 686 560, Kerala, India

    Sabu Thomas

  4. Animal Biotechnology Centre, National Dairy Research Institute, Karnal, 132001, India

    Hruda Nanda Malik, Dinesh Kumar Singhal, Ayan Mukherjee & Dhruba Malakar

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  1. Robin Augustine
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Correspondence to Nandakumar Kalarikkal or Sabu Thomas.

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Augustine, R., Malik, H.N., Singhal, D.K. et al. Electrospun polycaprolactone/ZnO nanocomposite membranes as biomaterials with antibacterial and cell adhesion properties. J Polym Res 21, 347 (2014). https://doi.org/10.1007/s10965-013-0347-6

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