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Preparation of self-solidifying polymeric depots from PLEC-PEG-PLEC triblock copolymers as an injectable drug delivery system

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Abstract

Copolymers of (D,L-lactide-random-ε-caprolactone)-block-poy(ethylene glycol)-block-(D,L-lactide-random-ε-caprolactone) or PLEC were explored as materials for injectable drug delivery system. A series of six PLECs were successfully synthesized with varied D,L-lactide (LA) content (0, 10 and 20%) and molecular weight (20 and 50 kDa). All polymers were able to form depots with more than 90% encapsulation efficiency of trypan blue leading to the loading density as high as 27% w/w. The variation of trypan blue loading, LA content and molecular weight were found to have profound effects on trypan blue release profiles. Even though, GPC and SEM confirmed the higher degradation of PLEC chains, trypan blue release rate and burst release was greater as the content of hydrophilic moiety, i.e. LA, was decreased. This was primarily due to the smooth and dense surface and cross-section of PLEC depots. The results from this study suggest a possible application of these depots as injectable, self-solidifying drug delivery systems.

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Acknowledgements

This work was supported by Mahidol University for Norased Nasongkla. Financial support for Wannarong Khamlao from the Center of Excellence for Innovation in Chemistry (PERCH-CIC), Commission on Higher Education, Ministry of Education is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Faculty of Engineering, Mahidol University, 25/25 Puttamonthon 4th Rd., Nakorn Pathom, 73170, Thailand

    Wannarong Khamlao & Norased Nasongkla

  2. Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand

    Suradej Hongeng

  3. Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand

    Wannarong Khamlao, Jitladda Sakdapipanich & Norased Nasongkla

Authors
  1. Wannarong Khamlao
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  2. Suradej Hongeng
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  3. Jitladda Sakdapipanich
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  4. Norased Nasongkla
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Corresponding author

Correspondence to Norased Nasongkla.

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Khamlao, W., Hongeng, S., Sakdapipanich, J. et al. Preparation of self-solidifying polymeric depots from PLEC-PEG-PLEC triblock copolymers as an injectable drug delivery system. J Polym Res 19, 9834 (2012). https://doi.org/10.1007/s10965-012-9834-4

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  • DOI: https://doi.org/10.1007/s10965-012-9834-4

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