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Apparent Solubility of Ibuprofen in Dimethyl Dodecyl Ammonium-Propane Sulfonate, DDAPS, Micelles, DDAPS/Butanol Mixtures and in Oil-in-Water Microemulsions Stabilized by DDAPS

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Abstract

Solubility of drugs in aqueous media is a real issue for scientists and a lot of work is going on to resolve the issue. The same is the case for ibuprofen, which is a derivative of propionic acid, belongs to the NSAIDs family and has low solubility in pure water. Therefore, its solubility has been investigated in dimethyl dodecyl ammonium-propane sulfonate, DDAPS, micellar solution, DDAPS/butanol mixtures and in various (hexane, decane and tetradecane) oil-in-water microemulsions to find out a suitable vehicle. The aggregation number, size and flow ability of micelles and microemulsions were estimated using refractive index, viscosity and light scattering measurements. It has been observed that these microemulsions have a higher ability to solubilize ibuprofen than DDAPS/butanol mixtures or DDAPS micelles.

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Acknowledgment

Mr. Irfan Ullah is thankful to Higher Education Commission, Pakistan for providing funds under IRSIP and Indigenous Fellowships Scheme. He pays special thanks to King’s College of London for providing laboratory facilities.

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Authors and Affiliations

  1. Department of Chemistry, Gomal University, Dera Ismail Khan, 29050, Pakistan

    Irfan Ullah & Musa Kaleem Baloch

  2. Agriculture Research Institute, Ratta Kulachi, Dera Ismail Khan, 29050, Pakistan

    Imran Ullah

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  1. Irfan Ullah
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  2. Musa Kaleem Baloch
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  3. Imran Ullah
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Correspondence to Irfan Ullah.

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Ullah, I., Baloch, M.K. & Ullah, I. Apparent Solubility of Ibuprofen in Dimethyl Dodecyl Ammonium-Propane Sulfonate, DDAPS, Micelles, DDAPS/Butanol Mixtures and in Oil-in-Water Microemulsions Stabilized by DDAPS. J Solution Chem 42, 657–665 (2013). https://doi.org/10.1007/s10953-013-9974-0

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