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Potentiometric and Thermodynamic Studies of Binary and Ternary Transition Metal(II) Complexes of Imidazole-4-acetic Acid and Some Bio-relevant Ligands

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Abstract

Proton–ligand association constants of imidazole-4-acetic acid (IMA) were determined potentiometrically in aqueous solution at different temperatures in the range 15–35 °C. The stepwise stability constants of IMA with some selected bivalent transition metal ions were also determined in 0.1 mol·dm−3 NaNO3. The stability of the complexes follows the trend Cu2+ > Ni2+ > Co2+ > Mn2+, which is in agreement with the Irving–Williams order of the metal ions. The thermodynamic parameters for Cu(II)–IMA complex formation were derived and discussed. The ternary complexes Cu(IMA)L (IMA = imidazole-4-acetic acid, HL = amino acid, amides or DNA constituents) have been investigated. Ternary complexes of amino acids or amides are formed by a simultaneous mechanism. Amino acids form the complex Cu(IMA)L, whereas amides form two complex species Cu(IMA)L and Cu(IMA)(LH−1). The DNA constituents form both 1:1 and 1:2 complexes. The stabilities of ternary complexes are quantitatively compared with their corresponding binary complexes. The concentration distribution of the complexes in solution was evaluated as a function of pH.

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Abbreviations

IMA:

Imidazole-4-acetic acid hydrochloride

GLuA:

Glutamine

Ino:

Inosine

Gly:

Glycine

Pyr:

Pyrocatecholate

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, 21589, Kingdom of Saudi Arabia

    M. Aljahdali

  2. Department of Chemistry, Faculty of Science, Cairo University, Cairo, Egypt

    Ahmed A. El-Sherif, Mohamed M. Shoukry & Seham E. Mohamed

  3. Department of Chemistry, Faculty of Arts and Science, Northern Borders University, Rafha, Kingdom of Saudi Arabia

    Ahmed A. El-Sherif

  4. Department of Chemistry, Faculty of Science, Islamic University, Madinah, Kingdom of Saudi Arabia

    Mohamed M. Shoukry

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  1. M. Aljahdali
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  2. Ahmed A. El-Sherif
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  3. Mohamed M. Shoukry
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  4. Seham E. Mohamed
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Correspondence to Ahmed A. El-Sherif.

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Aljahdali, M., El-Sherif, A.A., Shoukry, M.M. et al. Potentiometric and Thermodynamic Studies of Binary and Ternary Transition Metal(II) Complexes of Imidazole-4-acetic Acid and Some Bio-relevant Ligands. J Solution Chem 42, 1028–1050 (2013). https://doi.org/10.1007/s10953-013-0015-9

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