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Heteroaromatic thioamides: Structure and stability of charge transfer complexes with iodine, antithyroid activity

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Abstract

The review generalizes the structural studies on the products of the interaction of antithyroid preparations (heteroaromatic thioamides) with iodine. The n-σ* adducts of imidazol, thiazol, oxazole, pyridine, uracil derivatives with molecular iodine, iodinium salts, and also disulfides formed as a result of thione oxidation in iodine-coordinating solvents are considered. Based on mainly single crystal X-ray diffraction and Raman spectroscopy data, the structural parameters of iodine molecular complexes are shown to be highly sensitive to changes in the type of a heteroatom and substituents in the heteroring. The effect of the structure of heteroaromatic thioamides on their antithyroid activity is analyzed.

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  1. Southern Federal University, Rostov-on-Don, Russia

    M. S. Chernov’yants & A. O. Dolinkin

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Original Russian Text Copyright © 2010 by M. S. Chernov’yants and A. O. Dolinkin

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Translated from Zhurnal Strukturnoi Khimii, Vol. 51, No. 6, pp. 1211–1224, November–December, 2010.

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Chernov’yants, M.S., Dolinkin, A.O. Heteroaromatic thioamides: Structure and stability of charge transfer complexes with iodine, antithyroid activity. J Struct Chem 51, 1176–1190 (2010). https://doi.org/10.1007/s10947-010-0178-9

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