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Degradable and bioactive scaffold of calcium phosphate and calcium sulphate from self-setting cement for bone regeneration

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Abstract

Calcium sulphate/phosphate cement (CSPC) porous scaffolds were fabricated by introduction of calcium sulphate (CS) into calcium phosphate cement utilizing particle-leaching method. The morphology, porosity and mechanical strength as well as degradation of the CSPC scaffolds were characterized. The results reveal that the CSPC with 40 wt% CS content (40 CSPC) scaffolds with a porosity of 81% showed open macropores with the pore size of 200–500 μm. In addition, the 40 CSPC scaffolds with good degree of interconnected macropores degraded 60 wt% in Tris–HCl solution after 12 weeks. The proliferation, differentiation and morphology of MG63 cells on the 40 CSPC scaffolds were determined using MTT assay, ALP activity and SEM. The results suggest that the CSPC scaffolds could stimulate cell proliferation and differentiation, indicating that CSPC scaffolds were biocompatible and had no negative effects on the cells in vitro. The CSPC scaffolds were implanted in femur bone defect of rabbits, and the in vivo biocompatibility and osteogenicity of the scaffolds were investigated. The results indicate that CSPC scaffolds exhibited good biocompatibility, degradability and osteogenesis in vivo.

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Acknowledgments

The authors appreciate financial support Hangzhou Science & Technology Bureau.

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Authors and Affiliations

  1. The First People’s Hospital of Xiaoshang, 311201, Hangzhou, China

    Gangfeng Hu, Hong Fu, Dawei Bi & Haitao Ma

  2. Zhejiang Traditional Chinese Medical University, 310053, Hangzhou, China

    Gangfeng Hu, Luwei Xiao & Peijian Tong

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  1. Gangfeng Hu
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  2. Luwei Xiao
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  3. Hong Fu
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  4. Dawei Bi
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Correspondence to Luwei Xiao.

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Hu, G., Xiao, L., Fu, H. et al. Degradable and bioactive scaffold of calcium phosphate and calcium sulphate from self-setting cement for bone regeneration. J Porous Mater 17, 605–613 (2010). https://doi.org/10.1007/s10934-009-9330-3

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  • DOI: https://doi.org/10.1007/s10934-009-9330-3

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