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Intra-mammary Ductal Transplantation: A Tool to Study Premalignant Progression

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Journal of Mammary Gland Biology and Neoplasia Aims and scope Submit manuscript

Abstract

Ductal carcinoma in situ (DCIS) is a non-obligate precursor to invasive breast cancer. Although there is extensive information on the cellular and molecular changes in DCIS, there is limited ability to functionally test. The critical changes in premalignant progression. This review summarizes our experience with a recently developed method which provides. The opportunity to functionally test the molecular events occuring to functionally test the molecular events occurring in the initial changes in premaligant progression; i.e., the step from non-invasive to invasive behavior.

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Abbreviations

MIND:

Mouse intraductal

DCIS:

Ductal carcinoma in situ

IBC:

Invasive breast cancer

shRNAi:

short hairpin RNA inhibitor

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Authors and Affiliations

  1. Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA

    Daniel Medina, David G. Edwards & Frances Kittrell

  2. Department of Pathology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110, USA

    Sangjun Lee & D. Craig Allred

Authors
  1. Daniel Medina
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  2. David G. Edwards
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  3. Frances Kittrell
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  4. Sangjun Lee
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  5. D. Craig Allred
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Correspondence to Daniel Medina.

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Medina, D., Edwards, D.G., Kittrell, F. et al. Intra-mammary Ductal Transplantation: A Tool to Study Premalignant Progression. J Mammary Gland Biol Neoplasia 17, 131–133 (2012). https://doi.org/10.1007/s10911-012-9259-z

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  • DOI: https://doi.org/10.1007/s10911-012-9259-z

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