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Applications of Dendrimers in Nanomedicine and Drug Delivery: A Review

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Abstract

Dendrimers are hyper-branched organic compounds characterized via a three-dimensional structure possessing functional groups on the surface. These terminals groups can be simply modified to enhance the functionality of dendrimers and produce biocompatible and versatile products. They are a promising agent for nanomedicine applications because of their unique properties, including nanoscale size, globular shape, and high reactivity, solubility in water, internal cavities, and comfortable synthesis methods. The use of dendrimers as drug delivery systems have received great attention from researchers. Dendrimers can be applied as carriers for different therapeutic agents. They can reduce the toxicity of drugs and increase their efficacy. This review provides a general outline of the structure and types of dendrimers, the synthesis of dendrimers, and applications in the nanomedicine field with emphasis on drug delivery.

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Acknowledgements

This manuscript was supported by Pharmacotherapy Department, Faculty of Pharmacy, Bagyattallah University of Medical Sciences, and Tehran Iran.

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  1. Pharmacotherapy Department, Faculty of Pharmacy, Bagyattallah University of Medical Sciences, Tehran, Iran

    Mohammad Nikzamir & Yunes Panahi

  2. Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Abolfazl Akbarzadeh

  3. Department of Chemistry, Sayyed Jamaleddin Asadabadi University, Asadabad, Iran

    Younes Hanifehpour & Yunes Panahi

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  1. Mohammad Nikzamir
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Nikzamir, M., Hanifehpour, Y., Akbarzadeh, A. et al. Applications of Dendrimers in Nanomedicine and Drug Delivery: A Review. J Inorg Organomet Polym 31, 2246–2261 (2021). https://doi.org/10.1007/s10904-021-01925-2

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