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The Effect of Calcination Temperature on the Anticancer Activity of CaFe2O4@PVA Nanocarriers: Photodynamic Therapy and Drug Delivery Study

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Abstract

In this project, Calcium ferrite/polyvinyl alcohol (CaFe2O4@PVA) nanocarriers were prepared by a thermal-treatment method at three different temperatures (773, 823 and 923 K). The nanocarriers were used as drug delivery systems (DDS) to deliver curcumin (CUR) and were utilized as a new structure for photo dynamic therapy (PDT). Drug loading and release study of CUR were performed and it was observed that nanocarriers showed a pH dependent drug release behavior. MTT assay, Hemolysis assay and lethal dose test were applied to determine the cytotoxicity of nanocarriers. These tests indicated that synthesized nanocarriers can be considered as nontoxic. Also, the photodynamic therapy experiments were performed by two groups: one group of cells were treated by different concentrations of nanocarriers without light and the other group were exposed to light. Then, the efficacy of PDT was determined by MTT and it was revealed that whenever nanocarriers were exposed to light the cytotoxicity was significantly high. Therefore, it was revealed that these nanocarriers are suitable to be utilized as a drug delivery systems and photo dynamic therapy agent.

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Acknowledgements

This work has been supported financially by the Faculty of Pharmacy, Zanjan University of Medical Sciences and Malayer University. This work is a part of Dr. Ehsan Naderi’s Ph.D. thesis.

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Authors and Affiliations

  1. Department of Physics, Faculty of Science, Malayer University, Malayer, 95863-65719, Iran

    Ehsan Naderi & Mahmoud Naseri

  2. Department of Pharmaceutical Biomaterials, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran

    Mozhgan Aghajanzadeh, Mostafa Zamani & Hossein Danafar

  3. Department of Pharmaceutical Biotechnology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran

    Ali Sharafi

  4. Zanjan Pharmaceutical Nanotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran

    Hossein Danafar

Authors
  1. Ehsan Naderi
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  2. Mozhgan Aghajanzadeh
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  3. Mostafa Zamani
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  4. Ali Sharafi
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  5. Mahmoud Naseri
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  6. Hossein Danafar
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Correspondence to Mahmoud Naseri or Hossein Danafar.

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Naderi, E., Aghajanzadeh, M., Zamani, M. et al. The Effect of Calcination Temperature on the Anticancer Activity of CaFe2O4@PVA Nanocarriers: Photodynamic Therapy and Drug Delivery Study. J Inorg Organomet Polym 30, 5261–5269 (2020). https://doi.org/10.1007/s10904-020-01653-z

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  • DOI: https://doi.org/10.1007/s10904-020-01653-z

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