Study on the Magnetic and In Vitro Simulation Targeting Properties of Co²⁺ and Dy³⁺ Doped Square γ-Fe₂O₃ Nanoparticles

Abstract

Pure square γ-Fe₂O₃ and Co²⁺, Dy³⁺ doped γ-Fe₂O₃ nanoparticles were prepared by coprecipitation method, using ferrous sulfate as the iron source, and anhydrous CoCl₂, DyCl₃ as doping sources. Nano-magnetic structures and properties were characterized using transmission electron microscopy, X-ray diffraction, X-ray energy dispersive spectroscopy, vibrating sample magnetometer, Mössbauer spectrometer and fluorescence spectrophotometer. Effects of Co²⁺ and Dy³⁺ doping amount on their structures, morphologies, magnetic properties and PL properties were discussed. It was found that Co²⁺ and Dy³⁺ doped γ-Fe₂O₃ nanoparticles showed good fluorescent properties and better magnetic properties than pure γ-Fe₂O₃ with a saturation magnetization at 63.24 emu g⁻¹. Both the 7.56% Co²⁺ doped and 0.83% Dy³⁺ doped γ-Fe₂O₃ reached maximum saturation magnetization at 72.72 and 67.54 emu g⁻¹ respectively. In order to provide a reference for further magnetic targeting drug experiments and animal experiments, the “in vitro” simulation study of magnetic particle targeting in mimetic blood vessels was also carried out.