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Biologically Active Water Soluble Novel Biopolymer/Hydrazide Based O-Carboxymethyl Chitosan Schiff Bases: Synthesis and Characterisation

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Abstract

Six new N,N,O tridentate water soluble hydrazide based O-carboxymethyl chitosan Schiff base derivatives have been prepared through in-situ synthesis. The degree of substitution of schiff base derivatives was calculated theoretically and the derivatives were prepared with 1:1 proportion. Biopolymer Schiff base derivatives with their various bonding sites and different proton-carbon environment were characterised by FT-IR and 1H, 13C NMR. The crystallinity of synthesized Schiff bases was studied by X-ray diffraction. Thermal decomposition of all synthesized O-carboxymethyl chitosan Schiff base ligands was investigated by thermo gravimetric analysis which revealed the presence of Schiff base functionality to elongate the temperature to > 300 ºC. Scanning electron microscopic studies revealed that O-carboxymethyl chitosan Schiff base derivatives were affecting the crystallinity of chitosan. Additionally, the synthesized novel Schiff base derivatives were characterized for anti-inflammatory, total antioxidant and antidiabetic studies and they showed better biological and pharmaceutical results with standard drug.

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Acknowledgements

The authors thankful to the PG and Research Department of Chemistry, Islamiah College (Autonomous), Vaniyambadi, Tamil Nadu, India for availing needed laboratory and the Instrument facilities.

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Authors and Affiliations

  1. PG & Research Department of Chemistry, Islamiah College (Autonomous), Vaniyambadi, Vellore, Tamil Nadu, 635 752, India

    Murugaiyan Manimohan & Mohamed Aboobucker Sithique

  2. Department of Analytical Chemistry, University of Madras, Chennai, 600 025, India

    Sivashanmugam Pugalmani

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  1. Murugaiyan Manimohan
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Correspondence to Mohamed Aboobucker Sithique.

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Manimohan, M., Pugalmani, S. & Sithique, M.A. Biologically Active Water Soluble Novel Biopolymer/Hydrazide Based O-Carboxymethyl Chitosan Schiff Bases: Synthesis and Characterisation. J Inorg Organomet Polym 30, 3658–3676 (2020). https://doi.org/10.1007/s10904-020-01487-9

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