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Physical Crosslinked Poly(N-isopropylacrylamide)/Nano-Hydroxyapatite Thermosensitive Composite Hydrogels

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Abstract

Injectable and thermosensitive poly(N-isopropylacrylamide) (PNIPA)/nano-hydroxyapatite (nano-HA) composite hydrogels were synthesized by physical crosslinking of N-isopropylacrylamide with nano-HA as cross-linker to improve the mechanical property of hydrogels and avoid the use of chemical cross-linker. Internal morphology, thermosensitive, rheological, swelling, and hemocompatibility properties of the prepared hydrogels were investigated. The PNIPA/HA composite hydrogels had a phase transition from sol to gel, and the lowest critical solution temperature was about 32.5 °C. The PNIPA/HA composite hydrogels had regular pore structures and the nano-HA dispersed well throughout the network. Differential scanning calorimetry and thermogravimetric analysis showed that the addition of nano-HA had no significant effect on the LCST and thermal stability of the PNIPA/HA hydrogels. When the temperature was above 32.5 °C, the storage modulus (G′) and complex viscosity increased with the increasing nano-HA content. All PNIPA/HA composite hydrogels possessed the thinning behavior. The PNIPA/HA hydrogels exhibited a good water absorption capacity and the swelling ratio decreased with the increasing nano-HA content. As revealed by biocompatibility results, PNIPA/HA composite hydrogels were considered to be a non-hemolytic biomaterial. Therefore, PNIPA/HA hydrogels can be used as injectable materials for the potential applications of science and technology, such as tissue engineering scaffolds.

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Acknowledgements

The author thanks Chunhui Li for his assistance in the assay of scanning electron microscopy and Xiaonan Dai for her technical assistance of rheological tests.

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Authors and Affiliations

  1. College of Chemistry and Material Science, Shandong Agricultural University, 61 Daizong Street, Tai′an, Shandong, 271018, People’s Republic of China

    Shuo Wang, Zhaofu Zhang & Lifang Li

  2. Department of Pediatric Orthopedics, Tai’an Central Hospital, Tai’an, Shandong, 271000, People’s Republic of China

    Qihai Zhang

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  1. Shuo Wang
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  2. Zhaofu Zhang
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  3. Qihai Zhang
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  4. Lifang Li
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Correspondence to Qihai Zhang or Lifang Li.

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Wang, S., Zhang, Z., Zhang, Q. et al. Physical Crosslinked Poly(N-isopropylacrylamide)/Nano-Hydroxyapatite Thermosensitive Composite Hydrogels. J Inorg Organomet Polym 28, 2069–2079 (2018). https://doi.org/10.1007/s10904-018-0893-9

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  • DOI: https://doi.org/10.1007/s10904-018-0893-9

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