Skip to main content
SpringerLink
Log in

Family History of Prostate Cancer in a Black Population

  • Original Paper
  • Published:
Journal of Immigrant and Minority Health Aims and scope Submit manuscript

Abstract

Although family history of prostate cancer (PC) is an established risk factor for the disease, few studies have investigated this relationship among men with an African heritage. The Prostate Cancer in a Black Population (PCBP) study is a large, nationwide case–control study conducted in Barbados, West Indies from 2002 to 2011. In the PCBP study, a family history of PC in fathers or brothers was associated with a threefold increased risk of disease (OR = 3.04, 95 % CI (2.18, 4.22)) and a strong positive relationship was noted for the number of affected first degree relatives. Tumor grade did not generally influence the relationship between family history and PC. The magnitude of risks associated with having a father affected with the disease was slightly higher in the PCBP study compared to other populations. It remains unclear whether this finding is the result of an increased genetic susceptibility in African-Barbadian men.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Cancer Facts and Figures. 2011–2012; Available from: http://www.cancer.org/Research/CancerFactsFigures/CancerFactsFigures/index.

  2. Bruner DW, Moore D, Parlanti A, Dorgan J, Engstrom P. Relative risk of prostate cancer for men with affected relatives: systematic review and meta-analysis. Int J Cancer. 2003;107:797–803.

    Article  PubMed  CAS  Google Scholar 

  3. Johns LE, Houlston RS. A systematic review and meta-analysis of familial prostate cancer risk. BJU Int. 2003;91:789–94.

    Article  PubMed  CAS  Google Scholar 

  4. Zeegers MP, Jellema A, Ostrer H. Empiric risk of prostate carcinoma for relatives of patients with prostate carcinoma: a meta-analysis. Cancer. 2003;97:1894–903.

    Article  PubMed  Google Scholar 

  5. Nemesure B, Wu SY, Hennis A, Leske MC. Central adiposity and prostate cancer in a black population. Cancer Epidemiol Biomarkers Prev. 2012;21:851–8.

    Article  PubMed  Google Scholar 

  6. Benn-Torres J, Bonilla C, Robbins CM, Waterman L, Moses TY, Hernandez W, et al. Admixture and population stratification in African Caribbean populations. Ann Hum Genet. 2008;72:90–8.

    PubMed  CAS  Google Scholar 

  7. Hennis AJ, Hambleton IR, Wu SY, Skeete DH, Nemesure B, Leske MC. Prostate cancer incidence and mortality in Barbados, West indies. Prostate Cancer. 2011;2011:565230.

    Article  PubMed  Google Scholar 

  8. Hayes RB, Liff JM, Pottern LM, Greenberg RS, Schoenberg JB, Schwartz AG, et al. Prostate cancer risk in U.S. blacks and whites with a family history of cancer. Int J Cancer. 1995;60:361–4.

    Article  PubMed  CAS  Google Scholar 

  9. Whittemore AS, Wu AH, Kolonel LN, John EM, Gallagher RP, Howe GR, et al. Family history and prostate cancer risk in black, white, and Asian men in the United States and Canada. Am J Epidemiol. 1995;141:732–40.

    PubMed  CAS  Google Scholar 

  10. Sanderson M, Coker AL, Logan P, Zheng W, Fadden MK. Lifestyle and prostate cancer among older African-American and Caucasian men in South Carolina. Cancer Causes Control. 2004;15:647–55.

    Article  PubMed  Google Scholar 

  11. Glover FE Jr, Coffey DS, Douglas LL, Russell H, Cadigan M, Tulloch T, et al. Familial study of prostate cancer in Jamaica. Urology. 1998;52:441–3.

    Article  PubMed  Google Scholar 

  12. Lesko SM, Rosenberg L, Shapiro S. Family history and prostate cancer risk. Am J Epidemiol. 1996;144:1041–7.

    Article  PubMed  CAS  Google Scholar 

  13. Steinberg GD, Carter BS, Beaty TH, Childs B, Walsh PC. Family history and the risk of prostate cancer. Prostate. 1990;17:337–47.

    Article  PubMed  CAS  Google Scholar 

  14. Beebe-Dimmer JL, Drake EA, Dunn RL, Bock CH, Montie JE, Cooney KA. Association between family history of prostate and breast cancer among African–American men with prostate cancer. Urology. 2006;68:1072–6.

    Article  PubMed  Google Scholar 

  15. Ghadirian P, Howe GR, Hislop TG, Maisonneuve P. Family history of prostate cancer: a multi-center case-control study in Canada. Int J Cancer. 1997;70:679–81.

    Article  PubMed  CAS  Google Scholar 

  16. Hemminki K, Czene K. Age specific and attributable risks of familial prostate carcinoma from the family-cancer database. Cancer. 2002;95:1346–53.

    Article  PubMed  Google Scholar 

  17. Rodriguez C, Calle EE, Miracle-McMahill HL, Tatham LM, Wingo PA, Thun MJ, et al. Family history and risk of fatal prostate cancer. Epidemiology. 1997;8:653–7.

    PubMed  CAS  Google Scholar 

  18. Cerhan JR, Parker AS, Putnam SD, Chiu BC, Lynch CF, Cohen MB, et al. Family history and prostate cancer risk in a population-based cohort of Iowa men. Cancer Epidemiol Biomarkers Prev. 1999;8:53–60.

    PubMed  CAS  Google Scholar 

  19. Chen YC, Page JH, Chen R, Giovannucci E. Family history of prostate and breast cancer and the risk of prostate cancer in the PSA era. Prostate. 2008;68:1582–91.

    Article  PubMed  Google Scholar 

  20. King TM, Tong L, Pack RJ, Spencer C, Amos CI. Accuracy of family history of cancer as reported by men with prostate cancer. Urology. 2002;59:546–50.

    Article  PubMed  Google Scholar 

  21. Ziogas A, Anton-Culver H. Validation of family history data in cancer family registries. Am J Prev Med. 2003;24:190–8.

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

We would like to acknowledge the Barbados National Cancer Study Group:.

Investigators: Coordinating Center: M. Cristina Leske, MD, MPH; Barbara Nemesure, PhD; Suh-Yuh Wu, MA; Department of Preventive Medicine, Stony Brook Medicine, Stony Brook, NY

Clinical Center: Anselm Hennis, MBBS, PhD, FRCP; Winston Scott Polyclinic, Bridgetown, Barbados

Local Laboratory Center: Lyndon Waterman, PhD; University of the West Indies, Bridgetown, Barbados

Gene Discovery Center: John Carpten, PhD; Jeffrey Trent, PhD; Translational Genomics Research Institute, Phoenix, AZ

NHGRI: Joan Bailey-Wilson, PhD; National Human Genome Research Institute, Bethesda, MD

Nutritional Collaborator: Sangita Sharma, PhD; Department of Medicine, University of Alberta, Edmonton, Canada

Barbados Advisory Committee: Professor Trevor A. Hassell, GCM, MBBS, FRCP, FACC; Professor Henry Fraser, GCM, MBBS, FRCP, FACP; Dr. Jerry Emtage, MBBS, FRCS(C); Mr. Selwyn Ferdinand, MBBS, FRCS (Ed); The Honourable Mr. Justice W. Leroy Inniss, QC; Dr. Timothy Roach, MBBS, FRCP; Dr. Gina Watson [PAHO], Dr. Joy St. John [CMO].

Consultant Urologists: Dr. Jerry Emtage, MBBS, FRCS(C); Dr. Dave Padmore, MBBS, FRCS(C); Dr. Irving Smith, MBBS, FRCS.

Departments of Urology, Surgery, Pathology and Radiotherapy, Queen Elizabeth Hospital, Bridgetown, Barbados

This project was supported by the Intramural Research Program of the NIH, National Human Genome Research Institute (contract N01HG25487) and the National Cancer Institute (Grant R01CA114379).

Author information

Authors and Affiliations

  1. Department of Preventive Medicine, Stony Brook Medicine, Stony Brook, NY, 11794-8036, USA

    Barbara Nemesure, Suh-Yuh Wu, Anselm Hennis & M. Cristina Leske

  2. Chronic Disease Research Centre, University of the West Indies and Ministry of Health, Barbados, West Indies

    Anselm Hennis

Authors
  1. Barbara Nemesure
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Suh-Yuh Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Anselm Hennis
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. Cristina Leske
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Barbara Nemesure.

Additional information

The study was conducted by the Prostate Cancer in a Black Population Study Group and the article was written for the group.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nemesure, B., Wu, SY., Hennis, A. et al. Family History of Prostate Cancer in a Black Population. J Immigrant Minority Health 15, 1107–1112 (2013). https://doi.org/10.1007/s10903-012-9710-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10903-012-9710-7

Keywords

Search

Navigation