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Recent Development on Sensing Strategies for Small Molecules Detections

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Abstract

Sensors play a critical role in the detection and monitoring of various substances present in our environment, providing us with valuable information about the world around us. Within the field of sensor development, one area that holds particular importance is the detection of small molecules. Small molecules encompass a wide range of organic or inorganic compounds with low molecular weight, typically below 900 Daltons including gases, volatile organic compounds, solvents, pesticides, drugs, biomarkers, toxins, and pollutants. The accurate and efficient detection of these small molecules has attracted significant interest from the scientific community due to its relevance in diverse fields such as environmental pollutants monitoring, medical diagnostics, industrial optimization, healthcare remedies, food safety, ecosystems, and aquatic and terrestrial life preservation. To meet the demand for precise and efficient monitoring of small molecules, this summary aims to provide an overview of recent advancements in sensing and quantification strategies for various organic small molecules including Hydrazine, Glucose, Morpholine, Ethanol amine, Nitrosamine, Oxygen, Nitro-aromatics, Phospholipids, Carbohydrates, Antibiotics, Pesticides, Drugs, Adenosine Triphosphate, Aromatic Amine, Glutathione, Hydrogen Peroxide, Acetone, Methyl Parathion, and Thiophenol. The focus is on understanding the receptor sensing mechanism, along with the electrical, optical, and electrochemical response. Additionally, the variations in UV–visible spectral properties of the ligands upon treatment with the receptor, fluorescence and absorption titration analysis for limit of detection (LOD) determination, and bioimaging analysis are discussed wherever applicable. It is anticipated that the information gathered from this literature survey will be helpful for the perusal of innovation regarding sensing strategies.

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Data Availability Statement

Data will be available from corresponding author on demand.

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Acknowledgements

This study was supported by University of Sargodha and Thal University Bhakkar.

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Authors and Affiliations

  1. Department of Chemistry, University of Sargodha, Sargodha, Pakistan

    Muhammad Saleem

  2. Department of Chemistry, Thal University Bhakkar, Punjab, 30000, Bhakkar, Pakistan

    Muhammad Saleem

  3. Department of Chemistry, GC University Faisalabad, Sub Campus Layyah-31200, Layyah, Pakistan

    Muhammad Hanif

  4. Department of Physiology and Biochemistry, Cholistan University of Veterinary and Animal Sciences, Bahawalpur, 6300, Pakistan

    Muhammad Rafiq

  5. Department of Zoology, Mirpur University of Science and Technology (MUST), Mirpur, 10250, Pakistan

    Anser Ali

  6. Department of Biological Sciences, Kongju National University, Kongju, Chungnam, Republic of Korea

    Hussain Raza & Song Ja Kim

  7. Key Laboratory of Science and Technology of Eco-Textiles, Ministry of Education, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, China

    Changrui Lu

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  1. Muhammad Saleem
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  3. Muhammad Rafiq
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  6. Song Ja Kim
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  7. Changrui Lu
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Contributions

Material collection, data collection and write-up were performed by Muhammad Saleem, Muhammad Hanif and Muhammad Rafiq. Anser Ali, Hussain Raza, Dr. Kim Song Ja and Dr. Changrui Lu provide technical assistance.

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Correspondence to Muhammad Saleem.

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Saleem, M., Hanif, M., Rafiq, M. et al. Recent Development on Sensing Strategies for Small Molecules Detections. J Fluoresc (2023). https://doi.org/10.1007/s10895-023-03387-w

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